UniProt O60573
Eukaryotic translation initiation factor 4E type 2 (O60573)
Eukaryotic translation initiation factor 4E type 2 (UniProt O60573): 14 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 14 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- O60573
- Protein
- Eukaryotic translation initiation factor 4E type 2
- Experimental structures
- 14
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 14 · 2 records with a druggable one
Structures
15 records of O60573 in the MolNFT archive: 14 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2JGB | Structure of human eIF4E homologous protein 4EHP with m7GTP | x-ray diffraction | A | — | — |
| 2JGB | Structure of human EIF4E homologous protein 4EHP with M7GTP | x-ray diffraction | A | — | — |
| 2JGC | Structure of the human eIF4E homologous protein, 4EHP without ligand bound | x-ray diffraction | A | — | — |
| 2JGC | Structure of the human EIF4E homologous protein, 4EHP without ligand bound | x-ray diffraction | A | — | — |
| 5NVK | Crystal structure of the human 4EHP-GIGYF1 complex | x-ray diffraction | A, C, E, G | — | 12 (best 0.85) |
| 5NVK | Crystal structure of the human 4EHP-GIGYF1 complex | x-ray diffraction | A, C, E, G | — | — |
| 5NVL | Crystal structure of the human 4EHP-GIGYF2 complex | x-ray diffraction | A, C | — | — |
| 5NVL | Crystal structure of the human 4EHP-GIGYF2 complex | x-ray diffraction | A, C | — | — |
| 5NVM | Crystal structure of the human 4EHP-GIGYF2 complex lacking the auxiliary sequences | x-ray diffraction | A, C | PO4 | — |
| 5NVM | Crystal structure of the human 4EHP-GIGYF2 complex lacking the auxiliary sequences | x-ray diffraction | A, C | PO4 | — |
| 5NVN | Crystal structure of the human 4EHP-4E-BP1 complex | x-ray diffraction | A, C | — | — |
| 5NVN | Crystal structure of the human 4EHP-4E-BP1 complex | x-ray diffraction | A, C | — | — |
| 5XLN | Crystal structure of the TRS_UNE-T and 4EHP complex | x-ray diffraction | A | — | 1 (best 0.39) |
| 5XLN | Crystal structure of the TRS_UNE-T and 4EHP complex | x-ray diffraction | A | — | — |
| O60573 | AlphaFold monomer V2.0 prediction for eukaryotic translation initiation factor 4E type 2 (O60573) | predicted | A | — | 1 (best 0.66) |
Ligands
- PO4 · Phosphate ion · in 2 records
Experiment against prediction
- 5XLN chain A against the predicted model O60573: TM-score 0.99, RMSD 0.64 Å
- 5XLN chain A against the predicted model O60573: TM-score 0.99, RMSD 0.64 Å
- 5NVM chain C against the predicted model O60573: TM-score 0.97, RMSD 1.01 Å
- 5NVM chain C against the predicted model O60573: TM-score 0.97, RMSD 1.01 Å
- 5NVK chain E against the predicted model O60573: TM-score 0.97, RMSD 0.80 Å
- 5NVL chain C against the predicted model O60573: TM-score 0.97, RMSD 0.84 Å
- 5NVL chain C against the predicted model O60573: TM-score 0.97, RMSD 0.84 Å
- 5NVL chain A against the predicted model O60573: TM-score 0.97, RMSD 1.15 Å
- 5NVL chain A against the predicted model O60573: TM-score 0.97, RMSD 1.15 Å
- 2JGB chain A against the predicted model O60573: TM-score 0.96, RMSD 1.22 Å
Elsewhere
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