MolNFT v1 · #139634 · protein
Crystal structure of the TRS_UNE-T and 4EHP complex
5XLN · Eukaryotic translation initiation factor 4E type 2: “Crystal structure of the TRS_UNE-T and 4EHP complex”. X-ray diffraction, 1 pocket (best druggability 0.39). MolNFT v1 #139634 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 5XLN
- Type
- protein
- Length
- 191 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Eukaryotic translation initiation factor 4E type 2; Threonine--tRNA ligase, cytoplasmic
- EC
- 6.1.1.3
- UniProt
- O60573, P26639
- Pockets
- 1 · best druggability 0.39
Structure
x-ray diffraction · 2 distinct chains · 27% helix, 29% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Eukaryotic translation initiation factor 4E type 2 | protein | 165 | 24% helix, 33% strand | O60573 |
| B | Threonine--tRNA ligase, cytoplasmic (EC 6.1.1.3) | protein | 26 | 50% helix, 0% strand | P26639 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 127 | 0.39 | 0.74 | 25 | empty |
Interfaces
1 interface between chains.
- A–B · 805 Ų buried · 13 hydrogen bonds · protein-protein
Compared structures
- 5XLN · Crystal structure of the TRS_UNE-T and 4EHP complex · the same entry in another collection · chain A against A, TM-score 1.00
- O60573 · AlphaFold monomer V2.0 prediction for eukaryotic translation initiation factor 4E type 2… · a predicted model of the same protein · chain A against A, TM-score 0.99
- P26639 · AlphaFold monomer V2.0 prediction for threonine--tRNA ligase 1, cytoplasmic (P26639) · a predicted model of the same protein · chain B against A, TM-score 0.54
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O60573
- Every structure of UniProt P26639
- Elsewhere: RCSB PDB 5XLN · PDBe 5XLN · UniProt O60573 · UniProt P26639
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