MolNFT v1 · #40667 · protein

Streptavidin-biotin pH 10.44 I222 complex

2IZH: “Streptavidin-biotin pH 10.44 I222 complex”. X-ray diffraction, 1 ligand (BTN), 4 pockets (best druggability 0.46). MolNFT v1 #40667 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2IZH
Type: protein
Length: 244 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Streptavidin
UniProt: P22629
Ligands: BTN
Pockets: 4 · best druggability 0.46

Structure

x-ray diffraction · 1 distinct chain · 8% helix, 56% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
B, D	Streptavidin	protein	122	8% helix, 56% strand	P22629

Ligands and binding sites

BTN · Biotin · ligand · 2 copies · chains B, D

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	94	0.46	0.80	18	BTN
2	87	0.46	0.80	17	BTN
3	67	0.33	0.76	21	empty
4	50	0.26	0.74	17	empty

Interfaces

1 interface between chains.

B–D · 1609 Å² buried · 23 hydrogen bonds · protein-protein

Compared structures

2IZH · Streptavidin-biotin pH 10.44 I222 complex · the same entry in another collection · chain B against B, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P22629
Elsewhere: RCSB PDB 2IZH · PDBe 2IZH · UniProt P22629

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