MolNFT v1 · #40666 · protein
Streptavidin-biotin pH 2.0 I222 complex
2IZG: “Streptavidin-biotin pH 2.0 I222 complex”. X-ray diffraction, 2 ligands (BTN, SO4), 4 pockets (best druggability 0.48). MolNFT v1 #40666 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2IZG
- Type
- protein
- Length
- 244 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Streptavidin
- UniProt
- P22629
- Ligands
- BTN, SO4
- Pockets
- 4 · best druggability 0.48
Structure
x-ray diffraction · 2 distinct chains · 7% helix, 55% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | Streptavidin | protein | 123 | 8% helix, 55% strand | P22629 |
| D | Streptavidin | protein | 121 | 5% helix, 55% strand | P22629 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 97 | 0.48 | 0.80 | 17 | BTN |
| 2 | 91 | 0.46 | 0.80 | 17 | BTN |
| 3 | 82 | 0.37 | 0.77 | 20 | empty |
| 4 | 74 | 0.33 | 0.75 | 21 | empty |
Interfaces
1 interface between chains.
- B–D · 1608 Ų buried · 27 hydrogen bonds · protein-protein
Compared structures
- 2IZG · Streptavidin-biotin pH 2.0 I222 complex · the same entry in another collection · chain B against B, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P22629
- Elsewhere: RCSB PDB 2IZG · PDBe 2IZG · UniProt P22629
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