MolNFT v1 · #40274 · protein
Crystal structure of poliovirus polymerase complexed with UTP and MN2+
2IM3: “Crystal structure of poliovirus polymerase complexed with UTP and MN2+”. X-ray diffraction, 3 ligands (UTP, MN, NA), 4 pockets (best druggability 0.65). MolNFT v1 #40274 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2IM3
- Type
- protein
- Length
- 461 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Poliovirus polymerase
- EC
- 2.7.7.48
- UniProt
- P03300
- Ligands
- UTP, MN, NA
- Pockets
- 4 · best druggability 0.65
Structure
x-ray diffraction · 1 distinct chain · 43% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Poliovirus polymerase (EC 2.7.7.48) | protein | 461 | 43% helix, 16% strand | P03300 |
Ligands and binding sites
- UTP · Uridine 5'-triphosphate · ligand · chains A
- MN · Manganese (II) ion · metal · 2 copies · chains A
- NA · Sodium ion · metal · chains A
- ACY · Acetic acid · additive · 4 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 443 | 0.65 | 0.78 | 49 | MN, UTP |
| 2 | 263 | 0.58 | 0.78 | 30 | empty |
| 3 | 81 | 0.38 | 0.77 | 14 | empty |
| 4 | 83 | 0.36 | 0.75 | 18 | empty |
Modifications
Observed in the structure: 4 modified (artifact).
Compared structures
- 2IM3 · Crystal structure of poliovirus polymerase complexed with UTP and Mn2+ · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P03300
- Elsewhere: RCSB PDB 2IM3 · PDBe 2IM3 · UniProt P03300
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.