MolNFT v1 · #38967 · protein

Crystal structure of monomeric actin in the ADP bound state

2HF3 · Actin-5C: “Crystal structure of monomeric actin in the ADP bound state”. X-ray diffraction, 2 ligands (ADP, CA), 2 pockets (best druggability 0.73). MolNFT v1 #38967 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2HF3
Type: protein
Length: 364 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Actin-5C
UniProt: P10987
Ligands: ADP, CA
Pockets: 2 · best druggability 0.73

Structure

x-ray diffraction · 1 distinct chain · 46% helix, 19% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Actin-5C	protein	364	46% helix, 19% strand	P10987

Ligands and binding sites

ADP · Adenosine-5'-diphosphate · ligand · chains A
CA · Calcium ion · metal · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	489	0.73	0.82	55	CA, ADP
2	194	0.53	0.77	29	empty

Compared structures

2HF3 · Crystal structure of monomeric Actin in the ADP bound state · the same entry in another collection · chain A against A, TM-score 1.00
P10987 · AlphaFold monomer V2.0 prediction for actin-5C (P10987) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P10987
Elsewhere: RCSB PDB 2HF3 · PDBe 2HF3 · UniProt P10987

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.