MolNFT v1 · #38932 · protein

Crystal structure of the 3RD PDZ domain of human discs large homologue 2, DLG2

2HE2 · Discs large homolog 2: “Crystal structure of the 3RD PDZ domain of human discs large homologue 2, DLG2”. X-ray diffraction, 1 pocket (best druggability 0.36). MolNFT v1 #38932 on GenesisL1: 3D structure, binding sites and pockets in…

PDB: 2HE2
Type: protein
Length: 203 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Discs large homolog 2
UniProt: Q15700
Pockets: 1 · best druggability 0.36

Structure

x-ray diffraction · 2 distinct chains · 23% helix, 37% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Discs large homolog 2	protein	102	24% helix, 37% strand	Q15700
B	Discs large homolog 2	protein	101	23% helix, 38% strand	Q15700

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	74	0.36	0.77	17	empty

Interfaces

1 interface between chains.

A–B · 994 Å² buried · 30 hydrogen bonds · protein-protein

Compared structures

2HE2 · Crystal structure of the 3rd PDZ domain of human discs large homologue 2, DLG2 · the same entry in another collection · chain A against A, TM-score 1.00
Q15700 · AlphaFold monomer V2.0 prediction for disks large homolog 2 (Q15700) · a predicted model of the same protein · chain A against A, TM-score 0.95

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q15700
Elsewhere: RCSB PDB 2HE2 · PDBe 2HE2 · UniProt Q15700

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