MolNFT v1 · #98842 · protein

AlphaFold monomer V2.0 prediction for disks large homolog 2 (Q15700)

Q15700: “AlphaFold monomer V2.0 prediction for disks large homolog 2 (Q15700)”. 5 pockets (best druggability 0.72). MolNFT v1 #98842 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

Accession: Q15700
Type: protein
Length: 870 residues
Chains: 1
Collection: MolNFT v1 / AlphaFold
Contract: 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
Owner: 0xEa8958Be15002D4c0d41c2203589a54b6808a2AF
Molecule: Disks large homolog 2
UniProt: Q15700
Pockets: 5 · best druggability 0.72

Structure

1 distinct chain · 18% helix, 23% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Disks large homolog 2	protein	870	18% helix, 23% strand	Q15700

Pockets

5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1014	0.72	0.76	75	empty
2	576	0.64	0.75	49	empty
3	437	0.62	0.76	50	empty
4	87	0.34	0.74	13	empty
5	86	0.34	0.74	17	empty

Compared structures

2HE2 · Crystal structure of the 3rd PDZ domain of human discs large homologue 2, DLG2 · an experimental structure of the same protein · chain A against A, TM-score 0.12
2HE2 · Crystal structure of the 3RD PDZ domain of human discs large homologue 2, DLG2 · an experimental structure of the same protein · chain A against A, TM-score 0.12
2BYG · 2nd PDZ Domain of Discs Large Homologue 2 · an experimental structure of the same protein · chain A against A, TM-score 0.11
2BYG · 2ND PDZ domain of discs large homologue 2 · an experimental structure of the same protein · chain A against A, TM-score 0.11

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q15700
Elsewhere: UniProt Q15700 · AlphaFold DB Q15700

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