Research workbench

Crystal structure of the 3RD PDZ domain of human discs large homologue 2, DLG2

Analyse Crystal structure of the 3RD PDZ domain of human discs large homologue 2, DLG2 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2HE2
Type: protein
Length: 203 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Discs large homolog 2
UniProt: Q15700
Pockets: 1 · best druggability 0.36

Structure

x-ray diffraction · 2 distinct chains · 23% helix, 37% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Discs large homolog 2	protein	102	24% helix, 37% strand	Q15700
B	Discs large homolog 2	protein	101	23% helix, 38% strand	Q15700

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	74	0.36	0.77	17	empty

Interfaces

1 interface between chains.

A–B · 994 Å² buried · 30 hydrogen bonds · protein-protein

Compared structures

2HE2 · Crystal structure of the 3rd PDZ domain of human discs large homologue 2, DLG2 · the same entry in another collection · chain A against A, TM-score 1.00
Q15700 · AlphaFold monomer V2.0 prediction for disks large homolog 2 (Q15700) · a predicted model of the same protein · chain A against A, TM-score 0.95

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q15700
Elsewhere: RCSB PDB 2HE2 · PDBe 2HE2 · UniProt Q15700

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.