MolNFT v1 · #38856 · protein

Structure of the yeast nuclear exosome component, RRP6P, reveals an interplay between the active site and the hrdc domain

2HBJ · Exosome complex exonuclease RRP6: “Structure of the yeast nuclear exosome component, RRP6P, reveals an interplay between the active site and the…”. X-ray diffraction, 4 pockets (best druggability 0.68). MolNFT v1 #38856 on…

PDB: 2HBJ
Type: protein
Length: 390 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Exosome complex exonuclease RRP6
EC: 3.1.13.-
UniProt: Q12149
Pockets: 4 · best druggability 0.68

Structure

x-ray diffraction · 1 distinct chain · 43% helix, 9% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Exosome complex exonuclease RRP6 (EC 3.1.13.-)	protein	390	43% helix, 9% strand	Q12149

Pockets

4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	505	0.68	0.79	57	empty
2	212	0.59	0.80	28	empty
3	111	0.36	0.73	26	empty
4	88	0.36	0.75	15	empty

Compared structures

2HBJ · Structure of the yeast nuclear exosome component, Rrp6p, reveals an interplay between the… · the same entry in another collection · chain A against A, TM-score 1.00
Q12149 · AlphaFold monomer V2.0 prediction for exosome complex exonuclease RRP6 (Q12149) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q12149
Elsewhere: RCSB PDB 2HBJ · PDBe 2HBJ · UniProt Q12149

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