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Structure of the yeast nuclear exosome component, RRP6P, reveals an interplay between the active site and the hrdc domain

Analyse Structure of the yeast nuclear exosome component, RRP6P, reveals an interplay… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2HBJ
Type: protein
Length: 390 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Exosome complex exonuclease RRP6
EC: 3.1.13.-
UniProt: Q12149
Pockets: 4 · best druggability 0.68

Structure

x-ray diffraction · 1 distinct chain · 43% helix, 9% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Exosome complex exonuclease RRP6 (EC 3.1.13.-)	protein	390	43% helix, 9% strand	Q12149

Pockets

4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	505	0.68	0.79	57	empty
2	212	0.59	0.80	28	empty
3	111	0.36	0.73	26	empty
4	88	0.36	0.75	15	empty

Compared structures

2HBJ · Structure of the yeast nuclear exosome component, Rrp6p, reveals an interplay between the… · the same entry in another collection · chain A against A, TM-score 1.00
Q12149 · AlphaFold monomer V2.0 prediction for exosome complex exonuclease RRP6 (Q12149) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q12149
Elsewhere: RCSB PDB 2HBJ · PDBe 2HBJ · UniProt Q12149

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