UniProt Q12149
Exosome complex exonuclease RRP6 (Q12149)
Exosome complex exonuclease RRP6 (UniProt Q12149), EC 3.1.13.-: 24 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 20 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- Q12149
- Protein
- Exosome complex exonuclease RRP6
- EC
- 3.1.13.-
- Experimental structures
- 24
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 20 · 2 records with a druggable one
Structures
25 records of Q12149 in the MolNFT archive: 24 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2HBJ | Structure of the yeast nuclear exosome component, Rrp6p, reveals an interplay between the active… | x-ray diffraction | A | — | — |
| 2HBJ | Structure of the yeast nuclear exosome component, RRP6P, reveals an interplay between the active… | x-ray diffraction | A | — | — |
| 2HBK | Structure of the yeast nuclear exosome component, Rrp6p, reveals an interplay between the active… | x-ray diffraction | A | — | — |
| 2HBK | Structure of the yeast nuclear exosome component, RRP6P, reveals an interplay between the active… | x-ray diffraction | A | — | — |
| 2HBL | Structure of the yeast nuclear exosome component, Rrp6p, reveals an interplay between the active… | x-ray diffraction | A | — | — |
| 2HBL | Structure of the yeast nuclear exosome component, RRP6P, reveals an interplay between the active… | x-ray diffraction | A | — | — |
| 2HBM | Structure of the yeast nuclear exosome component, Rrp6p, reveals an interplay between the active… | x-ray diffraction | A | — | — |
| 2HBM | Structure of the yeast nuclear exosome component, RRP6P, reveals an interplay between the active… | x-ray diffraction | A | — | — |
| 4IFD | Crystal structure of an 11-subunit eukaryotic exosome complex bound to RNA | x-ray diffraction | K | — | — |
| 4IFD | Crystal structure of an 11-subunit eukaryotic exosome complex bound to RNA | x-ray diffraction | K | — | — |
| 4OO1 | Structure of an Rrp6-RNA exosome complex bound to poly(A) RNA | x-ray diffraction | J | — | — |
| 4OO1 | Structure of an RRP6-RNA exosome complex bound to POLY(A) RNA | x-ray diffraction | J | — | — |
| 4WFC | Structure of the Rrp6-Rrp47 interaction | x-ray diffraction | A, C, E | — | — |
| 4WFC | Structure of the RRP6-RRP47 interaction | x-ray diffraction | A, C, E | — | — |
| 4WFD | Structure of the Rrp6-Rrp47-Mtr4 interaction | x-ray diffraction | A, D, G | — | — |
| 4WFD | Structure of the RRP6-RRP47-MTR4 interaction | x-ray diffraction | A, D, G | — | — |
| 5C0W | Structure of a 12-subunit nuclear exosome complex bound to single- stranded RNA substrates | x-ray diffraction | K | — | — |
| 5C0X | Structure of a 12-subunit nuclear exosome complex bound to structured RNA | x-ray diffraction | K | — | — |
| 5C0Y | Crystal structure of the Rrp6 catalytic domain bound to poly(U) RNA | x-ray diffraction | A, B | MG | 12 (best 0.79) |
| 5C0Y | Crystal structure of the RRP6 catalytic domain bound to POLY(U) RNA | x-ray diffraction | A, B | — | — |
| 5K36 | Structure of an eleven component nuclear RNA exosome complex bound to RNA | x-ray diffraction | J | — | — |
| 5K36 | Structure of an eleven component nuclear RNA exosome complex bound to RNA | x-ray diffraction | J | — | — |
| 5VZJ | Structure of a twelve component MPP6-nuclear RNA exosome complex bound to RNA | x-ray diffraction | J | — | — |
| 6LQS | Cryo-EM structure of 90S small subunit preribosomes in transition states (State D) | electron microscopy | r6 | — | — |
| Q12149 | AlphaFold monomer V2.0 prediction for exosome complex exonuclease RRP6 (Q12149) | predicted | A | — | 8 (best 0.62) |
Ligands
- MG · Magnesium ion · in 1 record
Experiment against prediction
- 5C0Y chain B against the predicted model Q12149: TM-score 0.99, RMSD 0.58 Å
- 5C0Y chain B against the predicted model Q12149: TM-score 0.99, RMSD 0.58 Å
- 5C0Y chain A against the predicted model Q12149: TM-score 0.99, RMSD 0.89 Å
- 5C0Y chain A against the predicted model Q12149: TM-score 0.99, RMSD 0.89 Å
- 2HBM chain A against the predicted model Q12149: TM-score 0.98, RMSD 1.20 Å
- 2HBM chain A against the predicted model Q12149: TM-score 0.98, RMSD 1.20 Å
- 2HBK chain A against the predicted model Q12149: TM-score 0.98, RMSD 1.20 Å
- 2HBK chain A against the predicted model Q12149: TM-score 0.98, RMSD 1.20 Å
- 2HBL chain A against the predicted model Q12149: TM-score 0.98, RMSD 1.22 Å
- 2HBL chain A against the predicted model Q12149: TM-score 0.98, RMSD 1.22 Å
Elsewhere
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