MolNFT v1 · #38794 · protein
WDR5 in complex with unmodified H3K4 peptide
2H9M · Wd-repeat protein 5: “WDR5 in complex with unmodified H3K4 peptide”. X-ray diffraction, 3 pockets (best druggability 0.73). MolNFT v1 #38794 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2H9M
- Type
- protein
- Length
- 619 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Wd-repeat protein 5; H3 histone
- UniProt
- P61964, Q6P823
- Pockets
- 3 · best druggability 0.73
Structure
x-ray diffraction · 3 distinct chains · 0% helix, 49% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Wd-repeat protein 5 | protein | 304 | 0% helix, 50% strand | P61964 |
| B | H3 histone | protein | 6 | 0% helix, 0% strand | Q6P823 |
| D | H3 histone | protein | 5 | 0% helix, 0% strand | Q6P823 |
Pockets
3 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 486 | 0.73 | 0.82 | 45 | empty |
| 2 | 488 | 0.72 | 0.81 | 44 | empty |
| 3 | 411 | 0.62 | 0.77 | 49 | empty |
Interfaces
4 interfaces between chains.
- A–B · 498 Ų buried · 5 hydrogen bonds · protein-protein
- C–D · 459 Ų buried · 7 hydrogen bonds · protein-protein
- A–C · 136 Ų buried · 3 hydrogen bonds · protein-protein
- A–D · 69 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P61964
- Every structure of UniProt Q6P823
- Elsewhere: RCSB PDB 2H9M · PDBe 2H9M · UniProt P61964 · UniProt Q6P823
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