MolNFT v1 · #38693 · protein
Histone H3 recognition and presentation by the WDR5 module of the MLL1 complex
2H68 · Wd-repeat protein 5: “Histone H3 recognition and presentation by the WDR5 module of the MLL1 complex”. X-ray diffraction, 5 pockets (best druggability 0.85). MolNFT v1 #38693 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 2H68
- Type
- protein
- Length
- 610 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Wd-repeat protein 5
- UniProt
- P61964
- Pockets
- 5 · best druggability 0.85
Structure
x-ray diffraction · 2 distinct chains · 0% helix, 51% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Wd-repeat protein 5 | protein | 304 | 0% helix, 52% strand | P61964 |
| B | Wd-repeat protein 5 | protein | 306 | 0% helix, 50% strand | P61964 |
Pockets
5 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 835 | 0.85 | 0.87 | 69 | empty |
| 2 | 509 | 0.74 | 0.82 | 45 | empty |
| 3 | 175 | 0.54 | 0.79 | 28 | empty |
| 4 | 192 | 0.53 | 0.78 | 21 | empty |
| 5 | 216 | 0.51 | 0.76 | 32 | empty |
Interfaces
1 interface between chains.
- A–B · 497 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 2H68 · Histone H3 recognition and presentation by the WDR5 module of the MLL1 complex · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P61964
- Elsewhere: RCSB PDB 2H68 · PDBe 2H68 · UniProt P61964
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