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Histone H3 recognition and presentation by the WDR5 module of the MLL1 complex

Analyse Histone H3 recognition and presentation by the WDR5 module of the MLL1 complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2H68
Type: protein
Length: 610 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Wd-repeat protein 5
UniProt: P61964
Pockets: 5 · best druggability 0.85

Structure

x-ray diffraction · 2 distinct chains · 0% helix, 51% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Wd-repeat protein 5	protein	304	0% helix, 52% strand	P61964
B	Wd-repeat protein 5	protein	306	0% helix, 50% strand	P61964

Pockets

5 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	835	0.85	0.87	69	empty
2	509	0.74	0.82	45	empty
3	175	0.54	0.79	28	empty
4	192	0.53	0.78	21	empty
5	216	0.51	0.76	32	empty

Interfaces

1 interface between chains.

A–B · 497 Å² buried · 1 hydrogen bond · protein-protein

Compared structures

2H68 · Histone H3 recognition and presentation by the WDR5 module of the MLL1 complex · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P61964
Elsewhere: RCSB PDB 2H68 · PDBe 2H68 · UniProt P61964

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