MolNFT v1 · #38642 · protein
Karyopherin BETA2/TRANSPORTIN-M9NLS
2H4M · Transportin-1: “Karyopherin BETA2/TRANSPORTIN-M9NLS”. X-ray diffraction, 15 pockets (best druggability 0.67). MolNFT v1 #38642 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2H4M
- Type
- protein
- Length
- 1,687 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transportin-1; Heterogeneous nuclear ribonucleoprotein A1
- UniProt
- Q92973, P09651
- Pockets
- 15 · best druggability 0.67
Structure
x-ray diffraction · 4 distinct chains · 73% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Transportin-1 | protein | 827 | 77% helix, 0% strand | Q92973 |
| B | Transportin-1 | protein | 810 | 74% helix, 0% strand | Q92973 |
| C | Heterogeneous nuclear ribonucleoprotein A1 | protein | 23 | 0% helix, 4% strand | P09651 |
| D | Heterogeneous nuclear ribonucleoprotein A1 | protein | 27 | 0% helix, 4% strand | P09651 |
Pockets
15 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 324 | 0.67 | 0.82 | 29 | empty |
| 2 | 528 | 0.67 | 0.77 | 50 | empty |
| 3 | 275 | 0.64 | 0.81 | 36 | empty |
| 4 | 295 | 0.58 | 0.78 | 42 | empty |
| 5 | 125 | 0.55 | 0.82 | 21 | empty |
Interfaces
3 interfaces between chains.
- B–D · 1828 Ų buried · 28 hydrogen bonds · protein-protein
- A–C · 1468 Ų buried · 27 hydrogen bonds · protein-protein
- A–B · 800 Ų buried · 11 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 2H4M · Karyopherin Beta2/Transportin-M9NLS · the same entry in another collection · chain D against D, TM-score 1.00
- Q92973 · AlphaFold monomer V2.0 prediction for transportin-1 (Q92973) · a predicted model of the same protein · chain B against A, TM-score 0.95
- P09651 · AlphaFold monomer V2.0 prediction for heterogeneous nuclear ribonucleoprotein A1 (P09651) · a predicted model of the same protein · chain D against A, TM-score 0.24
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q92973
- Every structure of UniProt P09651
- Elsewhere: RCSB PDB 2H4M · PDBe 2H4M · UniProt Q92973 · UniProt P09651
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