UniProt P09651
Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed (P09651)
Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed (UniProt P09651): 50 experimental structures and 1 predicted model on GenesisL1, 8 ligands bound, 7 pockets. Binding sites, druggability and experiment against…
- UniProt
- P09651
- Protein
- Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed
- Experimental structures
- 50
- Predicted models
- 1
- Ligands
- 8
- Pockets
- 7 · 3 records with a druggable one
Structures
51 records of P09651 in the MolNFT archive: 50 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1HA1 | Hnrnp A1 (RBD1,2) from homo sapiens | x-ray diffraction | A | — | — |
| 1HA1 | Hnrnp A1 (RBD1,2) from homo sapiens | x-ray diffraction | A | — | — |
| 1L3K | UP1, the two RNA-recognition motif domain of hnrnp A1 | x-ray diffraction | A | — | — |
| 1L3K | UP1, the two RNA-recognition motif domain of hnrnp A1 | x-ray diffraction | A | — | — |
| 1PGZ | Crystal Structure of UP1 Complexed With d(TTAGGGTTAG(6-MI)G); A Human Telomeric Repeat Containing… | x-ray diffraction | A | — | — |
| 1PGZ | Crystal structure of UP1 complexed with D(TTAGGGTTAG(6-mi) G); a human telomeric repeat containing… | x-ray diffraction | A | — | — |
| 1PO6 | Crystal Structure of UP1 Complexed With d(TAGG(6MI)TTAGGG): A Human Telomeric Repeat Containing… | x-ray diffraction | A | — | — |
| 1PO6 | Crystal structure of UP1 complexed with D(TAGG(6MI)TTAGGG): a human telomeric repeat containing… | x-ray diffraction | A | — | — |
| 1U1K | Crystal Structure of UP1 Complexed With d(TTAGGGTT 7DA GGG); A Human Telomeric Repeat Containing… | x-ray diffraction | A | — | — |
| 1U1K | Crystal structure of UP1 complexed with D(TTAGGGTT 7DA ggg); a human telomeric repeat containing… | x-ray diffraction | A | — | — |
| 1U1L | Crystal Structure of UP1 Complexed With d(TTAGGGTT PRN GGG); A Human Telomeric Repeat Containing… | x-ray diffraction | A | — | — |
| 1U1L | Crystal structure of UP1 complexed with D(TTAGGGTT prn ggg); a human telomeric repeat containing… | x-ray diffraction | A | — | — |
| 1U1M | Crystal Structure of UP1 Complexed With d(TTAGGGTTA 7GU GG); A Human Telomeric Repeat Containing… | x-ray diffraction | A | — | — |
| 1U1M | Crystal structure of UP1 complexed with D(TTAGGGTTA 7GU gg); a human telomeric repeat containing… | x-ray diffraction | A | — | — |
| 1U1N | Crystal Structure of UP1 Complexed With d(TTAGGGTTA (PRN)GG); A Human Telomeric Repeat Containing… | x-ray diffraction | A | — | — |
| 1U1N | Crystal structure of UP1 complexed with D(TTAGGGTTA (prn) gg); a human telomeric repeat containing… | x-ray diffraction | A | — | — |
| 1U1O | Crystal Structure of UP1 Complexed With d(TTAGGGTTAG(DI)G); A Human Telomeric Repeat Containing… | x-ray diffraction | A | — | — |
| 1U1O | Crystal structure of UP1 complexed with D(TTAGGGTTAG(DI)G); a human telomeric repeat containing… | x-ray diffraction | A | — | — |
| 1U1P | Crystal Structure of UP1 Complexed With d(TTAGGGTTA 2PR GG); A Human Telomeric Repeat Containing… | x-ray diffraction | A | — | — |
| 1U1P | Crystal structure of UP1 complexed with D(TTAGGGTTA 2PR gg); a human telomeric repeat containing… | x-ray diffraction | A | — | — |
| 1U1Q | Crystal Structure of UP1 Complexed With d(TTAGGGTTA(DI)GG); A Human Telomeric Repeat Containing… | x-ray diffraction | A | — | — |
| 1U1Q | Crystal structure of UP1 complexed with D(TTAGGGTTA(DI)GG); a human telomeric repeat containing… | x-ray diffraction | A | — | — |
| 1U1R | Crystal Structure of UP1 Complexed With d(TTAGGGTTAG(2PR)G); A Human Telomeric Repeat Containing… | x-ray diffraction | A | — | — |
| 1U1R | Crystal structure of UP1 complexed with D(TTAGGGTTAG(2PR) G); a human telomeric repeat containing… | x-ray diffraction | A | — | — |
| 1UP1 | UP1, the two RNA-recognition motif domain of hnrnp A1 | x-ray diffraction | A | — | — |
| 1UP1 | UP1, the two RNA-recognition motif domain of hnrnp A1 | x-ray diffraction | A | — | — |
| 2H4M | Karyopherin Beta2/Transportin-M9NLS | x-ray diffraction | C, D | — | — |
| 2H4M | Karyopherin BETA2/TRANSPORTIN-M9NLS | x-ray diffraction | C, D | — | — |
| 2LYV | Solution structure of the two RRM domains of hnRNP A1 (UP1) using segmental isotope labeling | solution nmr | A | — | — |
| 2LYV | Solution structure of the two rrm domains of hnrnp A1 (UP1) using segmental isotope labeling | solution nmr | A | — | — |
| 2UP1 | Structure of UP1-telomeric DNA complex | x-ray diffraction | A | — | — |
| 2UP1 | Structure of UP1-telomeric DNA complex | x-ray diffraction | A | — | — |
| 4YOE | Structure of UP1 bound to RNA 5'-AGU-3' | x-ray diffraction | A | — | — |
| 4YOE | Structure of UP1 bound to RNA 5'-agu-3' | x-ray diffraction | A | — | — |
| 5MPG | Solution NMR structure of hnRNP A1 RRM1 in complex with 5'-UUAGGUC-3' RNA | solution nmr | A | — | — |
| 5MPG | Solution NMR structure of hnrnp A1 RRM1 in complex with 5'-uuagguc-3' RNA | solution nmr | A | — | — |
| 5MPL | Hnrnp A1 RRM2 in complex with 5'-ucaguu-3' RNA | solution nmr | A | — | — |
| 5ZGL | Hnrnp A1 segment gggyggs (residues 234-240) | x-ray diffraction | A, B | — | — |
| 6DCL | Crystal structure of UP1 bound to pri-miRNA-18A terminal loop | x-ray diffraction | A, B | — | — |
| 7BX7 | Cryo-EM structure of amyloid fibril formed by HNRNPA1 low complexity domain | electron microscopy | A, B, C, D, E, F | — | — |
| 7ZJ2 | Amyloid fibril (in vitro) from full-length hnRNPA1 protein | electron microscopy | A, B, C, D, E, F, G, H, I, J, K, L | — | — |
| 8RZV | Structure of UP1 S4ES6E phosphomimetic mutant in complex with human telomeric repeat DNA | x-ray diffraction | A | — | 1 (best 0.52) |
| 9F4D | UP1 in complex with Z1203107138 | x-ray diffraction | A | JH1 | — |
| 9F4H | UP1 in complex with Z106579662 | x-ray diffraction | A | NUY | 1 (best 0.29) |
| 9F4K | UP1 in complex with ZINC72259689 | x-ray diffraction | A | A1H9R | — |
| 9F4O | UP1 in complex with Z991506900 | x-ray diffraction | A | A1H95 | 1 (best 0.36) |
| 9F4W | UP1 in complex with Z54508609 | x-ray diffraction | A | O0M | — |
| 9F51 | UP1 in complex with Z608065044 | x-ray diffraction | A | A1H9V | — |
| 9F53 | UP1 in complex with Z237527902 | x-ray diffraction | A | K3A | 2 (best 0.50) |
| 9F55 | UP1 in complex with Z235361315 | x-ray diffraction | A | A1H9U | — |
| P09651 | AlphaFold monomer V2.0 prediction for heterogeneous nuclear ribonucleoprotein A1 (P09651) | predicted | A | — | 2 (best 0.63) |
Ligands
- A1H95 · (3~{R})-3-methyl-1-(6-methylpyridin-2-yl)piperazine · in 1 record
- A1H9R · ~{N}-(cyclobutylmethyl)-1,3-dimethyl-pyrazole-4-carboxamide · in 1 record
- A1H9U · ~{N}-(3-azanyl-2-methyl-phenyl)propanamide · in 1 record
- A1H9V · ~{N},~{N}-dimethyl-1~{H}-pyrazole-4-sulfonamide · in 1 record
- JH1 · 1-ethyl-N-[(4-fluorophenyl)methyl]-1H-pyrazole-4-carboxamide · in 1 record
- K3A · N-(5-methyl-1H-pyrazol-3-yl)acetamide · in 1 record
- NUY · [4-(propan-2-yl)piperazin-1-yl](thiophen-2-yl)methanone · in 1 record
- O0M · 1-{[4-(propan-2-yl)phenyl]methyl}piperidin-4-ol · in 1 record
Experiment against prediction
- 1U1R chain A against the predicted model P09651: TM-score 0.98, RMSD 0.70 Å
- 1U1R chain A against the predicted model P09651: TM-score 0.98, RMSD 0.70 Å
- 1U1P chain A against the predicted model P09651: TM-score 0.98, RMSD 0.72 Å
- 1U1P chain A against the predicted model P09651: TM-score 0.98, RMSD 0.72 Å
- 1U1N chain A against the predicted model P09651: TM-score 0.98, RMSD 0.72 Å
- 1U1N chain A against the predicted model P09651: TM-score 0.98, RMSD 0.72 Å
- 1U1M chain A against the predicted model P09651: TM-score 0.98, RMSD 0.73 Å
- 1U1M chain A against the predicted model P09651: TM-score 0.98, RMSD 0.73 Å
- 1U1L chain A against the predicted model P09651: TM-score 0.98, RMSD 0.73 Å
- 1U1L chain A against the predicted model P09651: TM-score 0.98, RMSD 0.73 Å
Elsewhere
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