MolNFT v1 · #38415 · protein

Spvb ADP-ribosylated actin: hexagonal crystal form

2GWJ · Actin, alpha skeletal muscle: “Spvb ADP-ribosylated actin: hexagonal crystal form”. X-ray diffraction, 2 ligands (ATP, CA), 2 pockets (best druggability 0.74). MolNFT v1 #38415 on GenesisL1: 3D structure, binding sites and pockets…

PDB: 2GWJ
Type: protein
Length: 360 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Actin, alpha skeletal muscle
UniProt: P68135
Ligands: ATP, CA
Pockets: 2 · best druggability 0.74

Structure

x-ray diffraction · 1 distinct chain · 46% helix, 21% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Actin, alpha skeletal muscle	protein	360	46% helix, 21% strand	P68135

Ligands and binding sites

ATP · Adenosine-5'-triphosphate · ligand · chains A
CA · Calcium ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	469	0.74	0.83	56	CA, ATP
2	83	0.34	0.74	19	empty

Modifications

Observed in the structure: 1 modified (methylation).

Compared structures

2GWJ · SpvB ADP-ribosylated actin: hexagonal crystal form · the same entry in another collection · chain A against A, TM-score 1.00
P68135 · AlphaFold monomer V2.0 prediction for actin, alpha skeletal muscle (P68135) · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P68135
Elsewhere: RCSB PDB 2GWJ · PDBe 2GWJ · UniProt P68135

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