MolNFT v1 · #37436 · protein

Cellular oxygen sensing: crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2)

2G19 · Egl nine homolog 1: “Cellular oxygen sensing: crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2)”. X-ray diffraction, 2 ligands (4HG, FE2), 1 pocket (best druggability 0.65). MolNFT v1 #37436 on GenesisL1: 3D…

PDB: 2G19
Type: protein
Length: 216 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Egl nine homolog 1
EC: 1.14.11.-
UniProt: Q9GZT9
Ligands: 4HG, FE2
Pockets: 1 · best druggability 0.65

Structure

x-ray diffraction · 1 distinct chain · 29% helix, 30% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Egl nine homolog 1 (EC 1.14.11.-)	protein	216	29% helix, 30% strand	Q9GZT9

Ligands and binding sites

4HG · N-[(4-hydroxy-8-iodoisoquinolin-3-yl)carbonyl]glycine · ligand · chains A
FE2 · Fe (II) ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	144	0.65	0.87	23	FE2, 4HG

Compared structures

2G19 · Cellular Oxygen Sensing: Crystal Structure of Hypoxia-Inducible Factor Prolyl Hydroxylase… · the same entry in another collection · chain A against A, TM-score 1.00
Q9GZT9 · AlphaFold monomer V2.0 prediction for egl nine homolog 1 (Q9GZT9) · a predicted model of the same protein · chain A against A, TM-score 0.94

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9GZT9
Elsewhere: RCSB PDB 2G19 · PDBe 2G19 · UniProt Q9GZT9

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