MolNFT v1 · #37326 · protein
X-ray structure of bistramide a- actin complex at 1.35 a resolution.
2FXU · Actin, alpha skeletal muscle: “X-ray structure of bistramide a- actin complex at 1.35 a resolution.”. X-ray diffraction, 3 ligands (ATP, BID, CA), 3 pockets (best druggability 0.74). MolNFT v1 #37326 on GenesisL1: 3D structure…
- PDB
- 2FXU
- Type
- protein
- Length
- 361 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Actin, alpha skeletal muscle
- UniProt
- P68135
- Ligands
- ATP, BID, CA
- Pockets
- 3 · best druggability 0.74
Structure
x-ray diffraction · 1 distinct chain · 44% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Actin, alpha skeletal muscle | protein | 361 | 44% helix, 20% strand | P68135 |
Ligands and binding sites
- ATP · Adenosine-5'-triphosphate · ligand · chains A
- BID · Bistramide A · ligand · chains A
- CA · Calcium ion · metal · 4 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 332 | 0.74 | 0.86 | 45 | CA, ATP |
| 2 | 115 | 0.42 | 0.76 | 20 | BID |
| 3 | 61 | 0.31 | 0.76 | 11 | empty |
Modifications
Observed in the structure: 1 modified (methylation).
Compared structures
- 2FXU · X-ray Structure of Bistramide A- Actin Complex at 1.35 A resolution. · the same entry in another collection · chain A against A, TM-score 1.00
- P68135 · AlphaFold monomer V2.0 prediction for actin, alpha skeletal muscle (P68135) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P68135
- Elsewhere: RCSB PDB 2FXU · PDBe 2FXU · UniProt P68135
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