MolNFT v1 · #36486 · protein

Crystal structure of human fatty acid binding protein 1 (FABP1)

2F73 · Fatty acid-binding protein, liver: “Crystal structure of human fatty acid binding protein 1 (FABP1)”. X-ray diffraction, 20 pockets (best druggability 0.85). MolNFT v1 #36486 on GenesisL1: 3D structure, binding sites and pockets in…

PDB: 2F73
Type: protein
Length: 1,082 residues
Chains: 8
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Fatty acid-binding protein, liver
UniProt: P07148
Pockets: 20 · best druggability 0.85

Structure

x-ray diffraction · 2 distinct chains · 10% helix, 59% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, C, D, E, F, H	Fatty acid-binding protein, liver	protein	135	10% helix, 56% strand	P07148
B, G	Fatty acid-binding protein, liver	protein	136	10% helix, 61% strand	P07148

Pockets

20 pockets found on a 1 Å grid, 11 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	233	0.85	0.97	39	empty
2	252	0.85	0.96	42	empty
3	272	0.84	0.95	44	empty
4	244	0.84	0.95	32	empty
5	226	0.84	0.96	31	empty

Interfaces

8 interfaces between chains.

B–C · 1088 Å² buried · 21 hydrogen bonds · protein-protein
A–B · 639 Å² buried · 4 hydrogen bonds · protein-protein
G–H · 639 Å² buried · 2 hydrogen bonds · protein-protein
C–D · 621 Å² buried · 6 hydrogen bonds · protein-protein
E–F · 541 Å² buried · 4 hydrogen bonds · protein-protein

Compared structures

2F73 · Crystal structure of human fatty acid binding protein 1 (FABP1) · the same entry in another collection · chain H against H, TM-score 1.00
P07148 · AlphaFold monomer V2.0 prediction for fatty acid-binding protein, liver (P07148) · a predicted model of the same protein · chain F against A, TM-score 0.91

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P07148
Elsewhere: RCSB PDB 2F73 · PDBe 2F73 · UniProt P07148

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