UniProt P07148
Fatty acid-binding protein, liver (P07148)
Fatty acid-binding protein, liver (UniProt P07148): 59 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 37 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P07148
- Protein
- Fatty acid-binding protein, liver
- Experimental structures
- 59
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 37 · 8 records with a druggable one
Structures
60 records of P07148 in the MolNFT archive: 59 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2F73 | Crystal structure of human fatty acid binding protein 1 (FABP1) | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 2F73 | Crystal structure of human fatty acid binding protein 1 (FABP1) | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 2L67 | Solution Structure of Human Apo L-FABP | solution nmr | A | — | — |
| 2L67 | Solution structure of human apo L-fabp | solution nmr | A | — | — |
| 2L68 | Solution Structure of Human Holo L-FABP | solution nmr | A | — | — |
| 2L68 | Solution structure of human holo L-fabp | solution nmr | A | — | — |
| 2LKK | Human L-FABP in complex with oleate | solution nmr | A | — | — |
| 2LKK | Human L-fabp in complex with oleate | solution nmr | A | — | — |
| 2PY1 | Solution structure of human liver fatty acid binding protein | solution nmr | A | — | — |
| 2PY1 | Solution structure of human liver fatty acid binding protein | solution nmr | A | — | — |
| 3B2H | Iodide derivative of human LFABP at high resolution | x-ray diffraction | A | — | — |
| 3B2H | Iodide derivative of human lfabp at high resolution | x-ray diffraction | A | — | — |
| 3B2I | Iodide derivative of human LFABP | x-ray diffraction | A | — | — |
| 3B2I | Iodide derivative of human lfabp | x-ray diffraction | A | — | — |
| 3B2J | Iodide derivative of human LFABP | x-ray diffraction | A | — | — |
| 3B2J | Iodide derivative of human lfabp | x-ray diffraction | A | — | — |
| 3B2K | Iodide derivative of human LFABP | x-ray diffraction | A | — | — |
| 3B2K | Iodide derivative of human lfabp | x-ray diffraction | A | — | — |
| 3B2L | Iodide derivative of human LFABP | x-ray diffraction | A | — | — |
| 3B2L | Iodide derivative of human lfabp | x-ray diffraction | A | — | — |
| 3STK | Crystal Structure of human LFABP complex with two molecules of palmitic acid (holo-LFABP) | x-ray diffraction | A | — | — |
| 3STK | Crystal structure of human lfabp complex with two molecules of palmitic acid (holo-lfabp) | x-ray diffraction | A | — | — |
| 3STM | Structure of human LFABP in complex with one molecule of palmitic acid | x-ray diffraction | X | — | — |
| 3STM | Structure of human lfabp in complex with one molecule of palmitic acid | x-ray diffraction | X | — | — |
| 3STN | Structure of human LFABP (apo-LFABP) | x-ray diffraction | A | — | — |
| 3STN | Structure of human lfabp (apo-lfabp) | x-ray diffraction | A | — | — |
| 3VG2 | Iodide derivative of human LFABP | x-ray diffraction | A | — | — |
| 3VG2 | Iodide derivative of human lfabp | x-ray diffraction | A | — | — |
| 3VG3 | Cadmium derivative of human LFABP | x-ray diffraction | A | — | — |
| 3VG3 | Cadmium derivative of human lfabp | x-ray diffraction | A | — | — |
| 3VG4 | Cadmium derivative of human LFABP | x-ray diffraction | A | — | — |
| 3VG4 | Cadmium derivative of human lfabp | x-ray diffraction | A | — | — |
| 3VG5 | Barium derivative of human LFABP | x-ray diffraction | A | — | — |
| 3VG5 | Barium derivative of human lfabp | x-ray diffraction | A | — | — |
| 3VG6 | Barium derivative of human LFABP | x-ray diffraction | A | — | — |
| 3VG6 | Barium derivative of human lfabp | x-ray diffraction | A | — | — |
| 3VG7 | Structure of human LFABP at high resolution from S-SAD | x-ray diffraction | A | — | — |
| 3VG7 | Structure of human lfabp at high resolution from S-sad | x-ray diffraction | A | — | — |
| 6DO6 | NMR solution structure of wild type apo HFABP1 at 308 K | solution nmr | A | — | — |
| 6DO7 | NMR solution structure of wild type hFABP1 with GW7647 | solution nmr | A | — | 1 (best 0.84) |
| 6DO7 | NMR solution structure of wild type HFABP1 with GW7647 | solution nmr | A | — | — |
| 6DRG | NMR solution structure of wild type hFABP1 with GW7647 | solution nmr | A | 2VN | 1 (best 0.85) |
| 6DRG | NMR solution structure of wild type HFABP1 with GW7647 | solution nmr | A | 2VN | — |
| 6MP4 | Human liver FABP1 bound to tetrahydrocannabinol | x-ray diffraction | A, B, C, D, E, F, G, H | TCI | — |
| 7DZE | Fabp ground state captured by XFELs | x-ray diffraction | A, B | PLM | 3 (best 0.83) |
| 7DZE | Fabp ground state captured by xfels | x-ray diffraction | A, B | PLM | — |
| 7DZF | Intermediate of FABP with a delay time of 10 ns | x-ray diffraction | A, B | PLM | 3 (best 0.84) |
| 7DZF | Intermediate of fabp with a delay time of 10 ns | x-ray diffraction | A, B | PLM | — |
| 7DZG | Intermediate of FABP with a delay time of 30 ns | x-ray diffraction | A, B | PLM | 3 (best 0.83) |
| 7DZG | Intermediate of fabp with a delay time of 30 ns | x-ray diffraction | A, B | PLM | — |
| 7DZH | Intermediate of fabp with a delay time of 100 ns | x-ray diffraction | A, B | PLM | — |
| 7DZI | Intermediate of fabp with a delay time of 300 ns | x-ray diffraction | A, B | PLM | — |
| 7DZJ | Fabp protein before hv | x-ray diffraction | A, B | PLM | 3 (best 0.83) |
| 7DZJ | Fabp protein before hv | x-ray diffraction | A, B | PLM | — |
| 7DZK | Fabp protein after hv | x-ray diffraction | A, B | PLM | — |
| 7DZL | A69C-M71L mutant of Fabp protein | x-ray diffraction | A, B | PLM | 3 (best 0.84) |
| 7DZL | A69C-M71L mutant of fabp protein | x-ray diffraction | A, B | PLM | — |
| 7FYA | Crystal Structure of apo human FABP1 - orthorhombic form | x-ray diffraction | A, B | — | — |
| 7G00 | Crystal Structure of human FABP1 in complex with 2-[[3-(5-tert-butyl-1,2,4-oxadiazol-3-yl)-4,5,6,7-t… | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P | WII, SCN | 20 (best 0.85) |
| P07148 | AlphaFold monomer V2.0 prediction for fatty acid-binding protein, liver (P07148) | predicted | A | — | — |
Ligands
- PLM · Palmitic acid · in 13 records
- 2VN · 2-[(4-{2-[(4-cyclohexylbutyl)(cyclohexylcarbamoyl) amino]ethyl}phenyl)sulfanyl]-2-methylpropanoic acid · in 2 records
- SCN · Thiocyanate ion · in 1 record
- TCI · (6aR,10aR)-6,6,9-trimethyl-3-pentyl-6a,7,8,10a-tetrahydro-6H-benzo[c]chromen-1-ol · in 1 record
- WII · 2-{[(3P)-3-(5-tert-butyl-1,2,4-oxadiazol-3-yl)-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]carbamoyl}cyclopent-1-ene-1-carboxylic acid · in 1 record
Experiment against prediction
- 3B2L chain A against the predicted model P07148: TM-score 0.99, RMSD 0.40 Å
- 3B2L chain A against the predicted model P07148: TM-score 0.99, RMSD 0.40 Å
- 3B2K chain A against the predicted model P07148: TM-score 0.97, RMSD 0.68 Å
- 3B2K chain A against the predicted model P07148: TM-score 0.97, RMSD 0.68 Å
- 3B2H chain A against the predicted model P07148: TM-score 0.97, RMSD 0.67 Å
- 3B2H chain A against the predicted model P07148: TM-score 0.97, RMSD 0.67 Å
- 3VG6 chain A against the predicted model P07148: TM-score 0.97, RMSD 0.68 Å
- 3VG6 chain A against the predicted model P07148: TM-score 0.97, RMSD 0.68 Å
- 3VG7 chain A against the predicted model P07148: TM-score 0.97, RMSD 0.67 Å
- 3VG7 chain A against the predicted model P07148: TM-score 0.97, RMSD 0.67 Å
Elsewhere
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