Research workbench
Crystal structure of human fatty acid binding protein 1 (FABP1)
Analyse Crystal structure of human fatty acid binding protein 1 (FABP1) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2F73
- Type
- protein
- Length
- 1,082 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Fatty acid-binding protein, liver
- UniProt
- P07148
- Pockets
- 20 · best druggability 0.85
Structure
x-ray diffraction · 2 distinct chains · 10% helix, 59% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C, D, E, F, H | Fatty acid-binding protein, liver | protein | 135 | 10% helix, 56% strand | P07148 |
| B, G | Fatty acid-binding protein, liver | protein | 136 | 10% helix, 61% strand | P07148 |
Pockets
20 pockets found on a 1 Å grid, 11 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 233 | 0.85 | 0.97 | 39 | empty |
| 2 | 252 | 0.85 | 0.96 | 42 | empty |
| 3 | 272 | 0.84 | 0.95 | 44 | empty |
| 4 | 244 | 0.84 | 0.95 | 32 | empty |
| 5 | 226 | 0.84 | 0.96 | 31 | empty |
Interfaces
8 interfaces between chains.
- B–C · 1088 Ų buried · 21 hydrogen bonds · protein-protein
- A–B · 639 Ų buried · 4 hydrogen bonds · protein-protein
- G–H · 639 Ų buried · 2 hydrogen bonds · protein-protein
- C–D · 621 Ų buried · 6 hydrogen bonds · protein-protein
- E–F · 541 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 2F73 · Crystal structure of human fatty acid binding protein 1 (FABP1) · the same entry in another collection · chain H against H, TM-score 1.00
- P07148 · AlphaFold monomer V2.0 prediction for fatty acid-binding protein, liver (P07148) · a predicted model of the same protein · chain F against A, TM-score 0.91
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P07148
- Elsewhere: RCSB PDB 2F73 · PDBe 2F73 · UniProt P07148
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.