MolNFT v1 · #36316 · protein
Crystal structure of the traf-like domain of HAUSP/USP7 bound to a P53 peptide
2F1X: “Crystal structure of the traf-like domain of HAUSP/USP7 bound to a P53 peptide”. X-ray diffraction, 3 pockets (best druggability 0.48). MolNFT v1 #36316 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2F1X
- Type
- protein
- Length
- 279 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- HAUSP/USP7
- UniProt
- Q93009, P04637
- Pockets
- 3 · best druggability 0.48
Structure
x-ray diffraction · 2 distinct chains · 6% helix, 52% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | HAUSP/USP7 | protein | 137 | 7% helix, 53% strand | Q93009, P04637 |
| B | HAUSP/USP7 | protein | 142 | 5% helix, 51% strand | Q93009, P04637 |
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 160 | 0.48 | 0.77 | 27 | empty |
| 2 | 148 | 0.45 | 0.77 | 32 | empty |
| 3 | 77 | 0.31 | 0.74 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 623 Ų buried · 15 hydrogen bonds · protein-protein
Compared structures
- 2F1X · Crystal structure of the TRAF-like domain of HAUSP/USP7 bound to a p53 peptide · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q93009
- Every structure of UniProt P04637
- Elsewhere: RCSB PDB 2F1X · PDBe 2F1X · UniProt Q93009 · UniProt P04637
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