UniProt Q93009
Ubiquitin carboxyl-terminal hydrolase 7 (Q93009)
Ubiquitin carboxyl-terminal hydrolase 7 (UniProt Q93009), EC 3.4.19.12: 97 experimental structures on GenesisL1, 22 ligands bound, 21 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q93009
- Protein
- Ubiquitin carboxyl-terminal hydrolase 7
- EC
- 3.4.19.12
- Experimental structures
- 97
- Predicted models
- 0
- Ligands
- 22
- Pockets
- 21 · 3 records with a druggable one
Structures
97 records of Q93009 in the MolNFT archive: 97 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1NB8 | Structure of the catalytic domain of USP7 (HAUSP) | x-ray diffraction | A, B | — | — |
| 1NB8 | Structure of the catalytic domain of USP7 (hausp) | x-ray diffraction | A, B | — | — |
| 1NBF | Crystal structure of a UBP-family deubiquitinating enzyme in isolation and in complex with… | x-ray diffraction | A, B, E | — | — |
| 1NBF | Crystal structure of a ubp-family deubiquitinating enzyme in isolation and in complex with… | x-ray diffraction | A, B, E | — | — |
| 1YY6 | The Crystal Structure of the N-terminal domain of HAUSP/USP7 complexed with an EBNA1 peptide | x-ray diffraction | A | — | — |
| 1YY6 | The crystal structure of the N-terminal domain of HAUSP/USP7 complexed with an EBNA1 peptide | x-ray diffraction | A | — | — |
| 1YZE | Crystal structure of the N-terminal domain of USP7/HAUSP. | x-ray diffraction | A, B, C | — | — |
| 1YZE | Crystal structure of the N-terminal domain of USP7/HAUSP. | x-ray diffraction | A, B, C | — | — |
| 2F1W | Crystal structure of the TRAF-like domain of HAUSP/USP7 | x-ray diffraction | A | — | — |
| 2F1W | Crystal structure of the traf-like domain of HAUSP/USP7 | x-ray diffraction | A | — | — |
| 2F1X | Crystal structure of the TRAF-like domain of HAUSP/USP7 bound to a p53 peptide | x-ray diffraction | A, B | — | — |
| 2F1X | Crystal structure of the traf-like domain of HAUSP/USP7 bound to a P53 peptide | x-ray diffraction | A, B | — | — |
| 2F1Y | Crystal structure of the TRAF-like domain of HAUSP/USP7 bound to a MDM2 peptide | x-ray diffraction | A | — | — |
| 2F1Y | Crystal structure of the traf-like domain of HAUSP/USP7 bound to a MDM2 peptide | x-ray diffraction | A | — | — |
| 2F1Z | Crystal structure of HAUSP | x-ray diffraction | A, B | — | — |
| 2F1Z | Crystal structure of hausp | x-ray diffraction | A, B | — | — |
| 2FOJ | The Crystal Structure of the N-terminal domain of HAUSP/USP7 complexed with p53 peptide 364-367 | x-ray diffraction | A | — | — |
| 2FOJ | The crystal structure of the N-terminal domain of HAUSP/USP7 complexed with P53 peptide 364-367 | x-ray diffraction | A | — | — |
| 2FOO | The Crystal Structure of the N-terminal domain of HAUSP/USP7 complexed with p53 peptide 359-362 | x-ray diffraction | A | — | — |
| 2FOO | The crystal structure of the N-terminal domain of HAUSP/USP7 complexed with P53 peptide 359-362 | x-ray diffraction | A | — | — |
| 2FOP | The Crystal Structure of the N-terminal domain of HAUSP/USP7 complexed with mdm2 peptide 147-150 | x-ray diffraction | A | — | — |
| 2FOP | The crystal structure of the N-terminal domain of HAUSP/USP7 complexed with MDM2 peptide 147-150 | x-ray diffraction | A | — | — |
| 2KVR | Solution NMR structure of human ubiquitin specific protease Usp7 UBL domain (residues 537-664).… | solution nmr | A | — | — |
| 2KVR | Solution NMR structure of human ubiquitin specific protease USP7 ubl domain (residues 537-664).… | solution nmr | A | — | — |
| 2XXN | Structure of the vIRF4-HAUSP TRAF domain complex | x-ray diffraction | A | — | — |
| 2XXN | Structure of the VIRF4-hausp traf domain complex | x-ray diffraction | A | — | — |
| 2YLM | Mechanism of USP7 (HAUSP) activation by its C-terminal ubiquitin-like domain (HUBL) and allosteric… | x-ray diffraction | A | — | — |
| 2YLM | Mechanism of USP7 (hausp) activation by its C-terminal ubiquitin-like domain (hubl) and allosteric… | x-ray diffraction | A | — | — |
| 3MQR | Crystal Structure of the USP7:HdmX(AHSS) complex | x-ray diffraction | A | — | — |
| 3MQR | Crystal structure of the USP7:HDMX(AHSS) complex | x-ray diffraction | A | — | — |
| 3MQS | Crystal Structure of the USP7:Hdm2(PSTS) complex | x-ray diffraction | C | — | — |
| 3MQS | Crystal structure of the USP7:HDM2(PSTS) complex | x-ray diffraction | C | — | — |
| 4JJQ | Crystal structure of usp7-ntd with an e2 enzyme | x-ray diffraction | A | — | — |
| 4JJQ | Crystal structure of USP7-ntd with an E2 enzyme | x-ray diffraction | A | — | — |
| 4KG9 | Crystal Structure Of USP7-NTD with MCM-BP | x-ray diffraction | A | — | — |
| 4KG9 | Crystal structure of USP7-ntd with mcm-bp | x-ray diffraction | A | — | — |
| 4M5W | Crystal structure of the USP7/HAUSP catalytic domain | x-ray diffraction | A | — | — |
| 4M5W | Crystal structure of the USP7/HAUSP catalytic domain | x-ray diffraction | A | — | — |
| 4M5X | Crystal structure of the USP7/HAUSP catalytic domain | x-ray diffraction | A, B | — | — |
| 4M5X | Crystal structure of the USP7/HAUSP catalytic domain | x-ray diffraction | A, B | — | — |
| 4PYZ | Crystal structure of the first two Ubl domains of Deubiquitylase USP7 | x-ray diffraction | A, B | — | — |
| 4PYZ | Crystal structure of the first two ubl domains of deubiquitylase USP7 | x-ray diffraction | A, B | — | — |
| 4WPH | Crystal structure of USP7 ubiquitin-like domains in compact conformation | x-ray diffraction | A, B | — | — |
| 4WPH | Crystal structure of USP7 ubiquitin-like domains in compact conformation | x-ray diffraction | A, B | — | — |
| 4WPI | Crystal structure of USP7 ubiquitin-like domains in extended conformation | x-ray diffraction | A, B | — | — |
| 4WPI | Crystal structure of USP7 ubiquitin-like domains in extended conformation | x-ray diffraction | A, B | — | — |
| 4YOC | Crystal Structure of human DNMT1 and USP7/HAUSP complex | x-ray diffraction | C | — | — |
| 4YOC | Crystal structure of human DNMT1 and USP7/HAUSP complex | x-ray diffraction | C | — | — |
| 4YSI | Structure of USP7 with a novel viral protein | x-ray diffraction | A | — | — |
| 4YSI | Structure of USP7 with a novel viral protein | x-ray diffraction | A | — | — |
| 4Z96 | Crystal structure of DNMT1 in complex with USP7 | x-ray diffraction | A | — | — |
| 4Z96 | Crystal structure of DNMT1 in complex with USP7 | x-ray diffraction | A | — | — |
| 4Z97 | Crystal structure of USP7 in complex with DNMT1(K1115Q) | x-ray diffraction | A | — | — |
| 4Z97 | Crystal structure of USP7 in complex with DNMT1(K1115Q) | x-ray diffraction | A | — | — |
| 5C56 | Crystal structure of USP7/HAUSP in complex with ICP0 | x-ray diffraction | A | — | — |
| 5C56 | Crystal structure of USP7/HAUSP in complex with ICP0 | x-ray diffraction | A | — | — |
| 5C6D | Crystal structure of USP7 in complex with UHRF1 | x-ray diffraction | A, B | — | — |
| 5FWI | Structure of USP7 catalytic domain and three ubl-domains | x-ray diffraction | C | — | — |
| 5GG4 | Crystal structure of USP7 with RNF169 peptide | x-ray diffraction | A, B, C, D | — | — |
| 5J7T | Molecular Understanding of USP7 Substrate Recognition and C-Terminal Activation | x-ray diffraction | A | — | — |
37 records more on the page itself.
Ligands
- SO4 · Sulfate ion · in 3 records
- ZN · Zinc ion · in 3 records
- 9HS · 7-chloro-3-({4-hydroxy-1-[(3S)-3-phenylbutanoyl]piperidin-4-yl}methyl)quinazolin-4(3H)-one · in 2 records
- 9QA · 7-chloro-3-{[4-hydroxy-1-(3-phenylpropanoyl)piperidin-4-yl]methyl}quinazolin-4(3H)-one · in 2 records
- AJJ · 4-[3-(1-methylpiperidin-4-yl)-1,2,4-oxadiazol-5-yl]phenol · in 2 records
- CA · Calcium ion · in 2 records
- 8JM · 4-[2-amino-4-ethyl-5-(1H-indazol-5-yl)pyridin-3-yl]phenol · in 1 record
- 8JP · 6'-amino-4'-ethyl-5'-(4-hydroxyphenyl)-N-methyl[3,3'-bipyridine]-6-carboxamide · in 1 record
- 8QQ · 3-[4-(aminomethyl)phenyl]-2-methyl-6-[[4-oxidanyl-1-[(3~{R})-4,4,4-tris(fluoranyl)-3-phenyl-butanoyl]piperidin-4-yl]methyl]pyrazolo[4,3-d]pyrimidin-7-one · in 1 record
- 8RN · 7-bromanyl-3-[[4-oxidanyl-1-[(3~{R})-3-phenylbutanoyl]piperidin-4-yl]methyl]thieno[3,2-d]pyrimidin-4-one · in 1 record
- 8WK · 5-[[1-[(3~{S})-4,4-bis(fluoranyl)-3-(3-fluoranylpyrazol-1-yl)butanoyl]-4-oxidanyl-piperidin-4-yl]methyl]-1-(4-fluorophenyl)pyrazolo[3,4-d]pyrimidin-4-one · in 1 record
- 8WN · ~{N}-[2-[4-[4-[(1-methyl-4-oxidanylidene-pyrazolo[3,4-d]pyrimidin-5-yl)methyl]-4-oxidanyl-piperidin-1-yl]carbonylphenyl]phenyl]ethanesulfonamide · in 1 record
- 9QD · N-[3-({4-hydroxy-1-[(3R)-3-phenylbutanoyl]piperidin-4-yl}methyl)-4-oxo-3,4-dihydroquinazolin-7-yl]-3-(4-methylpiperazin-1-yl)propanamide · in 1 record
- A1ICO · 7-methyl-3-[[4-oxidanyl-1-[(3~{R},4~{R})-3-phenyl-1-[(5-pyridin-4-yl-1,3-thiazol-2-yl)methyl]piperidin-4-yl]carbonyl-piperidin-4-yl]methyl]pyrrolo[2,3-d]pyrimidin-4-one · in 1 record
- CQ5 · 3-[[4-oxidanyl-1-[(3~{R})-3-phenylbutanoyl]piperidin-4-yl]methyl]-6-(2-pyrrolidin-1-ylethylamino)pyrimidin-4-one · in 1 record
- EIB · [(3s,3ar,4r,6z,9s,10e,11ar)-9-acetyloxy-6-(acetyloxymethyl)-3,10-dimethyl-2-oxidanylidene-3A,4, 5,8,9,11A-hexahydro-3H-cyclodeca[b]furan-4-yl] (E)-2-methyl-4-oxidanyl-but-2-enoate · in 1 record
- EZF · Methyl 4-[[4-[[3-[4-(aminomethyl)phenyl]-2-methyl-7-oxidanylidene-pyrazolo[4,3-d]pyrimidin-6-yl]methyl]-4-oxidanyl-piperidin-1-yl]methyl]-3-chloranyl-benzoate · in 1 record
- R3Y · 1-{[7-(5-chloro-2-{[(3R,4S)-4-fluoropyrrolidin-3-yl]oxy}-3-methylphenyl)thieno[3,2-b]pyridin-2-yl]methyl}-1H-pyrrole-2,5-dione · in 1 record
- R41 · [(2R)-7-(2-aminopyridin-4-yl)-5-chloro-2,3-dihydro-1-benzofuran-2-yl](piperazin-1-yl)methanone · in 1 record
- R44 · 1-({7-[(2R)-5-chloro-2-(piperazine-1-carbonyl)-2,3-dihydro-1-benzofuran-7-yl]thieno[3,2-b]pyridin-2-yl}methyl)-1H-pyrrole-2,5-dione · in 1 record
- R4D · 3-({4-hydroxy-1-[(2R)-2-methyl-3-phenylpropanoyl]piperidin-4-yl}methyl)quinazolin-4(3H)-one · in 1 record
- R4J · [(2R)-5-chloro-7-{2-[(2S)-1-chloro-2,3-dihydroxypropan-2-yl]thieno[3,2-b]pyridin-7-yl}-2,3-dihydro-1-benzofuran-2-yl](piperazin-1-yl)methanone · in 1 record
Experiment against prediction
- 2F1Y chain A against the predicted model Q00987: TM-score 0.27, RMSD 4.80 Å
Elsewhere
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