MolNFT v1 · #36252 · protein

Epi-biotin complex with core streptavidin

2F01: “Epi-biotin complex with core streptavidin”. X-ray diffraction, 2 ligands (BTN, BTQ), 2 pockets (best druggability 0.48). MolNFT v1 #36252 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2F01
Type: protein
Length: 241 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Streptavidin
UniProt: P22629
Ligands: BTN, BTQ
Pockets: 2 · best druggability 0.48

Structure

x-ray diffraction · 2 distinct chains · 5% helix, 56% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Streptavidin	protein	121	5% helix, 56% strand	P22629
B	Streptavidin	protein	120	5% helix, 56% strand	P22629

Ligands and binding sites

BTN · Biotin · ligand · 2 copies · chains A, B
BTQ · Epi-biotin · ligand · 2 copies · chains A, B
GOL · Glycerol · additive · 3 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	86	0.48	0.81	17	BTN, BTQ
2	90	0.46	0.80	19	BTN, BTQ

Interfaces

1 interface between chains.

A–B · 1550 Å² buried · 26 hydrogen bonds · protein-protein

Compared structures

2F01 · Epi-biotin complex with core streptavidin · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P22629
Elsewhere: RCSB PDB 2F01 · PDBe 2F01 · UniProt P22629

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