MolNFT v1 · #35158 · protein
Solution structure of the cytoplasmic region of NA+/H+ exchanger 1 complexed with essential cofactor calcineurin B homologous protein 1
2E30 · Calcium-binding protein P22: “Solution structure of the cytoplasmic region of NA+/H+ exchanger 1 complexed with essential cofactor…”. Solution nmr, 1 ligand (CA), 3 pockets (best druggability 0.46). MolNFT v1 #35158 on GenesisL1: 3D…
- PDB
- 2E30
- Type
- protein
- Length
- 238 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Calcium-binding protein P22; SODIUM/HYDROGEN exchanger 1
- UniProt
- Q99653, P19634
- Ligands
- CA
- Pockets
- 3 · best druggability 0.46
Structure
solution nmr · 2 distinct chains · 48% helix, 2% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Calcium-binding protein P22 | protein | 195 | 50% helix, 2% strand | Q99653 |
| B | SODIUM/HYDROGEN exchanger 1 | protein | 43 | 42% helix, 0% strand | P19634 |
Ligands and binding sites
- CA · Calcium ion · metal · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 59 | 0.46 | 0.84 | 20 | empty |
| 2 | 89 | 0.38 | 0.76 | 17 | empty |
| 3 | 51 | 0.29 | 0.75 | 9 | empty |
Interfaces
1 interface between chains.
- A–B · 1588 Ų buried · 10 hydrogen bonds · protein-protein
Compared structures
- 2E30 · Solution structure of the cytoplasmic region of Na+/H+ exchanger 1 complexed with… · the same entry in another collection · chain A against A, TM-score 1.00
- Q99653 · AlphaFold monomer V2.0 prediction for calcineurin B homologous protein 1 (Q99653) · a predicted model of the same protein · chain A against A, TM-score 0.69
- P19634 · AlphaFold monomer V2.0 prediction for SODIUM/HYDROGEN exchanger 1 (P19634) · a predicted model of the same protein · chain B against A, TM-score 0.53
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q99653
- Every structure of UniProt P19634
- Elsewhere: RCSB PDB 2E30 · PDBe 2E30 · UniProt Q99653 · UniProt P19634
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