MolNFT v1 · #34996 · protein
Crystal structure of nucleoside diphosphate kinase in complex with GTP analog
2DXF: “Crystal structure of nucleoside diphosphate kinase in complex with GTP analog”. X-ray diffraction, 2 ligands (GNP, CL), 6 pockets (best druggability 0.51). MolNFT v1 #34996 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 2DXF
- Type
- protein
- Length
- 307 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Nucleoside diphosphate kinase
- EC
- 2.7.4.6
- UniProt
- O58429
- Ligands
- GNP, CL
- Pockets
- 6 · best druggability 0.51
Structure
x-ray diffraction · 2 distinct chains · 44% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Nucleoside diphosphate kinase (EC 2.7.4.6) | protein | 153 | 45% helix, 18% strand | O58429 |
| B | Nucleoside diphosphate kinase (EC 2.7.4.6) | protein | 154 | 43% helix, 18% strand | O58429 |
Ligands and binding sites
- GNP · Phosphoaminophosphonic acid-guanylate ester · ligand · chains A
- CL · Chloride ion · ion · 4 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 134 | 0.51 | 0.80 | 22 | GNP |
| 2 | 142 | 0.49 | 0.78 | 22 | empty |
| 3 | 131 | 0.39 | 0.74 | 20 | CL |
| 4 | 110 | 0.35 | 0.73 | 15 | empty |
| 5 | 79 | 0.34 | 0.75 | 21 | empty |
Interfaces
1 interface between chains.
- A–B · 1107 Ų buried · 19 hydrogen bonds · protein-protein
Compared structures
- 2DXF · Crystal structure of nucleoside diphosphate kinase in complex with GTP analog · the same entry in another collection · chain A against A, TM-score 1.00
- O58429 · AlphaFold monomer V2.0 prediction for nucleoside diphosphate kinase (O58429) · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O58429
- Elsewhere: RCSB PDB 2DXF · PDBe 2DXF · UniProt O58429
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