MolNFT v1 · #3462 · protein
Syk tyrosine kinase C-terminal SH2 domain complexed with a phosphopeptidefrom the gamma chain of the high affinity immunoglobin G receptor, NMR
1CSY · Syk protein tyrosine kinase: “Syk tyrosine kinase C-terminal SH2 domain complexed with a phosphopeptidefrom the gamma chain of the high…”. Solution nmr, 2 ligands (ACE, NH2). MolNFT v1 #3462 on GenesisL1: 3D structure, binding sites…
- PDB
- 1CSY
- Type
- protein
- Length
- 117 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Syk protein tyrosine kinase; Acetyl-thr-ptr-glu-thr-leu-NH2
- EC
- 2.7.1.112
- UniProt
- P43405
- Ligands
- ACE, NH2
Structure
solution nmr · 2 distinct chains · 15% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Syk protein tyrosine kinase (EC 2.7.1.112) | protein | 112 | 15% helix, 19% strand | P43405 |
| B | Acetyl-thr-ptr-glu-thr-leu-NH2 | protein | 5 | 0% helix, 0% strand | — |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Interfaces
1 interface between chains.
- A–B · 522 Ų buried · 7 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 covalent, 1 modified (covalent ligand, phosphorylation).
Compared structures
- 1CSY · Syk tyrosine kinase C-terminal SH2 domain complexed with a phosphopeptidefrom the gamma… · the same entry in another collection · chain B against B, TM-score 1.00
- P43405 · AlphaFold monomer V2.0 prediction for tyrosine-protein kinase syk (P43405) · a predicted model of the same protein · chain A against A, TM-score 0.77
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P43405
- Elsewhere: RCSB PDB 1CSY · PDBe 1CSY · UniProt P43405
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