Bovine trypsin in complex with squash seed inhibitor (cucurbita pepo trypsin inhibitor II)

Structure

x-ray diffraction · 2 distinct chains · 10% helix, 35% strand (DSSP).

Ligands and binding sites

• CA · Calcium ion · metal · chains E

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

• E–I · 830 Ų buried · 16 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 9 disulfide (disulfide).

Compared structures

• 2BTC · Bovine trypsin in complex with squash seed inhibitor (cucurbita pepo trypsin inhibitor II) · the same entry in another collection · chain E against E, TM-score 1.00
• 1TNG · Prediction of novel serine protease inhibitors · a predicted model of the same protein · chain E against A, TM-score 1.00
• 1TNI · Prediction of novel serine protease inhibitors · a predicted model of the same protein · chain E against A, TM-score 1.00
• 1TNH · Prediction of novel serine protease inhibitors · a predicted model of the same protein · chain E against A, TM-score 1.00
• 1TNJ · Prediction of novel serine protease inhibitors · a predicted model of the same protein · chain E against A, TM-score 1.00
• 1TNL · Prediction of novel serine protease inhibitors · a predicted model of the same protein · chain E against A, TM-score 1.00
• 1TNK · Prediction of novel serine protease inhibitors · a predicted model of the same protein · chain E against A, TM-score 1.00
• P10293 · AlphaFold monomer V2.0 prediction for trypsin inhibitor 3 (P10293) · a predicted model of the same protein · chain I against A, TM-score 0.90

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P00760
• Every structure of UniProt P10293
• Elsewhere: RCSB PDB 2BTC · PDBe 2BTC · UniProt P00760 · UniProt P10293