MolNFT v1 · #31819 · protein
Yeast guanine nucleotide exchange factor EEF1BALPHA K205A mutant in complex with EEF1A and GDP
2B7B · Elongation factor 1-alpha: “Yeast guanine nucleotide exchange factor EEF1BALPHA K205A mutant in complex with EEF1A and GDP”. X-ray diffraction, 1 ligand (GDP), 6 pockets (best druggability 0.79). MolNFT v1 #31819 on GenesisL1: 3D…
- PDB
- 2B7B
- Type
- protein
- Length
- 530 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Elongation factor 1-alpha; Elongation factor-1 beta
- UniProt
- P02994, P32471
- Ligands
- GDP
- Pockets
- 6 · best druggability 0.79
Structure
x-ray diffraction · 2 distinct chains · 21% helix, 36% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Elongation factor 1-alpha | protein | 440 | 22% helix, 35% strand | P02994 |
| B | Elongation factor-1 beta | protein | 90 | 19% helix, 46% strand | P32471 |
Ligands and binding sites
- GDP · Guanosine-5'-diphosphate · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1154 | 0.79 | 0.81 | 107 | empty |
| 2 | 302 | 0.66 | 0.82 | 42 | GDP |
| 3 | 133 | 0.40 | 0.74 | 19 | empty |
| 4 | 91 | 0.38 | 0.76 | 19 | empty |
| 5 | 63 | 0.35 | 0.78 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 1786 Ų buried · 28 hydrogen bonds · protein-protein
Compared structures
- 2B7B · Yeast guanine nucleotide exchange factor eEF1Balpha K205A mutant in complex with eEF1A… · the same entry in another collection · chain A against A, TM-score 1.00
- P32471 · AlphaFold monomer V2.0 prediction for elongation factor 1-beta (P32471) · a predicted model of the same protein · chain B against A, TM-score 0.98
- P02994 · AlphaFold monomer V2.0 prediction for elongation factor 1-alpha (P02994) · a predicted model of the same protein · chain A against A, TM-score 0.79
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P02994
- Every structure of UniProt P32471
- Elsewhere: RCSB PDB 2B7B · PDBe 2B7B · UniProt P02994 · UniProt P32471
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