Research workbench
Yeast guanine nucleotide exchange factor EEF1BALPHA K205A mutant in complex with EEF1A and GDP
Analyse Yeast guanine nucleotide exchange factor EEF1BALPHA K205A mutant in complex… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2B7B
- Type
- protein
- Length
- 530 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Elongation factor 1-alpha; Elongation factor-1 beta
- UniProt
- P02994, P32471
- Ligands
- GDP
- Pockets
- 6 · best druggability 0.79
Structure
x-ray diffraction · 2 distinct chains · 21% helix, 36% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Elongation factor 1-alpha | protein | 440 | 22% helix, 35% strand | P02994 |
| B | Elongation factor-1 beta | protein | 90 | 19% helix, 46% strand | P32471 |
Ligands and binding sites
- GDP · Guanosine-5'-diphosphate · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1154 | 0.79 | 0.81 | 107 | empty |
| 2 | 302 | 0.66 | 0.82 | 42 | GDP |
| 3 | 133 | 0.40 | 0.74 | 19 | empty |
| 4 | 91 | 0.38 | 0.76 | 19 | empty |
| 5 | 63 | 0.35 | 0.78 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 1786 Ų buried · 28 hydrogen bonds · protein-protein
Compared structures
- 2B7B · Yeast guanine nucleotide exchange factor eEF1Balpha K205A mutant in complex with eEF1A… · the same entry in another collection · chain A against A, TM-score 1.00
- P32471 · AlphaFold monomer V2.0 prediction for elongation factor 1-beta (P32471) · a predicted model of the same protein · chain B against A, TM-score 0.98
- P02994 · AlphaFold monomer V2.0 prediction for elongation factor 1-alpha (P02994) · a predicted model of the same protein · chain A against A, TM-score 0.79
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P02994
- Every structure of UniProt P32471
- Elsewhere: RCSB PDB 2B7B · PDBe 2B7B · UniProt P02994 · UniProt P32471
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