MolNFT v1 · #31592 · protein
Crystal structure of porcine pancreatic phospholipase A2 in complex with cholate
2AZY · Phospholipase A2, major isoenzyme: “Crystal structure of porcine pancreatic phospholipase A2 in complex with cholate”. X-ray diffraction, 2 ligands (CHD, CA), 1 pocket (best druggability 0.68). MolNFT v1 #31592 on GenesisL1: 3D…
- PDB
- 2AZY
- Type
- protein
- Length
- 124 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Phospholipase A2, major isoenzyme
- EC
- 3.1.1.4
- UniProt
- P00592
- Ligands
- CHD, CA
- Pockets
- 1 · best druggability 0.68
Structure
x-ray diffraction · 1 distinct chain · 52% helix, 9% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Phospholipase A2, major isoenzyme (EC 3.1.1.4) | protein | 124 | 52% helix, 9% strand | P00592 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 382 | 0.68 | 0.81 | 39 | CHD |
Modifications
Observed in the structure: 7 disulfide (disulfide).
Compared structures
- 2AZY · Crystal Structure of Porcine Pancreatic Phospholipase A2 in Complex with Cholate · the same entry in another collection · chain A against A, TM-score 1.00
- P00592 · AlphaFold monomer V2.0 prediction for phospholipase A2, major isoenzyme (P00592) · a predicted model of the same protein · chain A against A, TM-score 0.92
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P00592
- Elsewhere: RCSB PDB 2AZY · PDBe 2AZY · UniProt P00592
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.