Crystal structure of glucooligosaccharide oxidase from acremonium strictum: a novel flavinylation of 6-S-cysteinyl, 8ALPHA-N1-histidyl FAD

Structure

x-ray diffraction · 1 distinct chain · 33% helix, 22% strand (DSSP).

Ligands and binding sites

• FAD · Flavin-adenine dinucleotide · ligand · chains A
• ABL · (2R,3R,4R,5R)-4,5-dihydroxy-2-(hydroxymethyl)-6-oxopiperidin-3-yl beta-D-glucopyranoside · ligand · chains A
• NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 2 copies · chains A
• ZN · Zinc ion · metal · 4 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Modifications

Observed in the structure: 2 cofactor, 2 glycan, 1 disulfide (flavinylation, N-glycosylation, disulfide).

Compared structures

• 2AXR · Crystal structure of glucooligosaccharide oxidase from Acremonium strictum: a novel… · the same entry in another collection · chain A against A, TM-score 1.00
• Q6PW77 · AlphaFold monomer V2.0 prediction for glucooligosaccharide oxidase (Q6PW77) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q6PW77
• Elsewhere: RCSB PDB 2AXR · PDBe 2AXR · UniProt Q6PW77