MolNFT v1 · #30949 · protein
The 1.58A crystal structure of human coproporphyrinogen oxidase reveals the structural basis of hereditary coproporphyria
2AEX · Coproporphyrinogen III oxidase, mitochondrial: “The 1.58A crystal structure of human coproporphyrinogen oxidase reveals the structural basis of hereditary…”. X-ray diffraction, 4 pockets (best druggability 0.76). MolNFT v1 #30949 on…
- PDB
- 2AEX
- Type
- protein
- Length
- 336 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Coproporphyrinogen III oxidase, mitochondrial
- EC
- 1.3.3.3
- UniProt
- P36551
- Pockets
- 4 · best druggability 0.76
Structure
x-ray diffraction · 1 distinct chain · 42% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Coproporphyrinogen III oxidase, mitochondrial (EC 1.3.3.3) | protein | 336 | 42% helix, 24% strand | P36551 |
Ligands and binding sites
- CIT · Citric acid · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 217 | 0.76 | 0.91 | 39 | CIT |
| 2 | 128 | 0.52 | 0.80 | 21 | empty |
| 3 | 79 | 0.41 | 0.79 | 22 | empty |
| 4 | 53 | 0.35 | 0.79 | 14 | empty |
Compared structures
- 2AEX · The 1.58A Crystal Structure of Human Coproporphyrinogen Oxidase Reveals the Structural… · the same entry in another collection · chain A against A, TM-score 1.00
- P36551 · AlphaFold monomer V2.0 prediction for oxygen-dependent coproporphyrinogen-III oxidase… · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P36551
- Elsewhere: RCSB PDB 2AEX · PDBe 2AEX · UniProt P36551
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