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The 1.58A crystal structure of human coproporphyrinogen oxidase reveals the structural basis of hereditary coproporphyria
Analyse The 1.58A crystal structure of human coproporphyrinogen oxidase reveals the… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2AEX
- Type
- protein
- Length
- 336 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Coproporphyrinogen III oxidase, mitochondrial
- EC
- 1.3.3.3
- UniProt
- P36551
- Pockets
- 4 · best druggability 0.76
Structure
x-ray diffraction · 1 distinct chain · 42% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Coproporphyrinogen III oxidase, mitochondrial (EC 1.3.3.3) | protein | 336 | 42% helix, 24% strand | P36551 |
Ligands and binding sites
- CIT · Citric acid · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 217 | 0.76 | 0.91 | 39 | CIT |
| 2 | 128 | 0.52 | 0.80 | 21 | empty |
| 3 | 79 | 0.41 | 0.79 | 22 | empty |
| 4 | 53 | 0.35 | 0.79 | 14 | empty |
Compared structures
- 2AEX · The 1.58A Crystal Structure of Human Coproporphyrinogen Oxidase Reveals the Structural… · the same entry in another collection · chain A against A, TM-score 1.00
- P36551 · AlphaFold monomer V2.0 prediction for oxygen-dependent coproporphyrinogen-III oxidase… · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P36551
- Elsewhere: RCSB PDB 2AEX · PDBe 2AEX · UniProt P36551
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