MolNFT v1 · #30542 · protein
Crystal structure of SIAH1 sbd bound to the peptide ekpaavvapittg from sip
2A25 · Ubiquitin ligase SIAH1: “Crystal structure of SIAH1 sbd bound to the peptide ekpaavvapittg from sip”. X-ray diffraction, 1 ligand (ZN). MolNFT v1 #30542 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2A25
- Type
- protein
- Length
- 155 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ubiquitin ligase SIAH1; Calcyclin-binding protein peptide
- EC
- 6.3.2.-
- UniProt
- Q8IUQ4, Q9HB71
- Ligands
- ZN
Structure
x-ray diffraction · 2 distinct chains · 15% helix, 48% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Ubiquitin ligase SIAH1 (EC 6.3.2.-) | protein | 146 | 16% helix, 49% strand | Q8IUQ4 |
| B | Calcyclin-binding protein peptide | protein | 9 | 0% helix, 44% strand | Q9HB71 |
Ligands and binding sites
- ZN · Zinc ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Interfaces
1 interface between chains.
- A–B · 577 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
- 2A25 · Crystal structure of Siah1 SBD bound to the peptide EKPAAVVAPITTG from SIP · the same entry in another collection · chain A against A, TM-score 1.00
- Q8IUQ4 · AlphaFold monomer V2.0 prediction for E3 ubiquitin-protein ligase SIAH1 (Q8IUQ4) · a predicted model of the same protein · chain A against A, TM-score 0.99
- Q9HB71 · AlphaFold monomer V2.0 prediction for calcyclin-binding protein (Q9HB71) · a predicted model of the same protein · chain B against A, TM-score 0.44
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8IUQ4
- Every structure of UniProt Q9HB71
- Elsewhere: RCSB PDB 2A25 · PDBe 2A25 · UniProt Q8IUQ4 · UniProt Q9HB71
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.