UniProt Q8IUQ4
E3 ubiquitin-protein ligase SIAH1 (Q8IUQ4)
E3 ubiquitin-protein ligase SIAH1 (UniProt Q8IUQ4), EC 2.3.2.27, 6.3.2.-: 17 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 13 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q8IUQ4
- Protein
- E3 ubiquitin-protein ligase SIAH1
- EC
- 2.3.2.27, 6.3.2.-
- Experimental structures
- 17
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 13 · 2 records with a druggable one
Structures
18 records of Q8IUQ4 in the MolNFT archive: 17 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2A25 | Crystal structure of Siah1 SBD bound to the peptide EKPAAVVAPITTG from SIP | x-ray diffraction | A | — | — |
| 2A25 | Crystal structure of SIAH1 sbd bound to the peptide ekpaavvapittg from sip | x-ray diffraction | A | — | — |
| 4C9Z | Crystal structure of Siah1 at 1.95 A resolution | x-ray diffraction | A, B | — | — |
| 4C9Z | Crystal structure of SIAH1 at 1.95 a resolution | x-ray diffraction | A, B | — | — |
| 4CA1 | Crystal structure of Siah1 at 1.58 A resolution. | x-ray diffraction | A, B | — | — |
| 4CA1 | Crystal structure of SIAH1 at 1.58 a resolution. | x-ray diffraction | A, B | — | — |
| 4I7B | Siah1 bound to synthetic peptide (ACE)KLRPV(ABA)MVRPTVR | x-ray diffraction | A, C | — | — |
| 4I7B | SIAH1 bound to synthetic peptide (ACE)KLRPV(ABA)MVRPTVR | x-ray diffraction | A, C | — | — |
| 4I7C | Siah1 mutant bound to synthetic peptide (ACE)KLRPV(23P)MVRPWVR | x-ray diffraction | A, C | — | — |
| 4I7C | SIAH1 mutant bound to synthetic peptide (ACE)KLRPV(23P)MVRPWVR | x-ray diffraction | A, C | — | — |
| 4I7D | Siah1 bound to synthetic peptide (ACE)KLRPVAMVRP(PRK)VR | x-ray diffraction | A, C | — | — |
| 4I7D | SIAH1 bound to synthetic peptide (ACE)KLRPVAMVRP(PRK)VR | x-ray diffraction | A, C | — | — |
| 4X3G | Crystal structure of SIAH1 SINA domain in complex with a USP19 peptide | x-ray diffraction | A, B | — | — |
| 4X3G | Crystal structure of SIAH1 sina domain in complex with a USP19 peptide | x-ray diffraction | A, B | — | — |
| 5WZZ | The SIAH E3 ubiquitin ligases promote Wnt/ beta-catenin signaling through mediating Wnt-induced… | x-ray diffraction | A, B, C, D | ZN | 9 (best 0.71) |
| 5WZZ | The siah E3 ubiquitin ligases promote wnt/ beta-catenin signaling through mediating wnt-induced… | x-ray diffraction | A, B, C, D | ZN | — |
| 8HEO | Crystal structure of SIAH1 SBD bound to Axin2 peptide | x-ray diffraction | A, B | ZN | 3 (best 0.62) |
| Q8IUQ4 | AlphaFold monomer V2.0 prediction for E3 ubiquitin-protein ligase SIAH1 (Q8IUQ4) | predicted | A | — | 1 (best 0.35) |
Ligands
- ZN · Zinc ion · in 3 records
Experiment against prediction
- 2A25 chain A against the predicted model Q8IUQ4: TM-score 0.99, RMSD 0.47 Å
- 2A25 chain A against the predicted model Q8IUQ4: TM-score 0.99, RMSD 0.47 Å
- 4I7B chain C against the predicted model Q8IUQ4: TM-score 0.98, RMSD 0.74 Å
- 4I7B chain C against the predicted model Q8IUQ4: TM-score 0.98, RMSD 0.74 Å
- 4X3G chain B against the predicted model Q8IUQ4: TM-score 0.97, RMSD 0.90 Å
- 4X3G chain B against the predicted model Q8IUQ4: TM-score 0.97, RMSD 0.90 Å
- 4I7C chain C against the predicted model Q8IUQ4: TM-score 0.97, RMSD 1.10 Å
- 4I7C chain C against the predicted model Q8IUQ4: TM-score 0.97, RMSD 1.10 Å
- 4I7C chain A against the predicted model Q8IUQ4: TM-score 0.97, RMSD 1.13 Å
- 4I7C chain A against the predicted model Q8IUQ4: TM-score 0.97, RMSD 1.13 Å
Elsewhere
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