MolNFT v1 · #138948 · protein
The siah E3 ubiquitin ligases promote wnt/ beta-catenin signaling through mediating wnt-induced axin degradation
5WZZ: “The siah E3 ubiquitin ligases promote wnt/ beta-catenin signaling through mediating wnt-induced axin…”. X-ray diffraction, 1 ligand (ZN). MolNFT v1 #138948 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5WZZ
- Type
- protein
- Length
- 801 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- Q8IUQ4, O15169
- Ligands
- ZN
Structure
x-ray diffraction · 4 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | — | protein | 190 | — | Q8IUQ4 |
| E, H | — | protein | 11 | — | O15169 |
| F | — | protein | 9 | — | O15169 |
| G | — | protein | 10 | — | O15169 |
Ligands and binding sites
- ZN · Zinc ion · metal · 8 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 5WZZ · The SIAH E3 ubiquitin ligases promote Wnt/ beta-catenin signaling through mediating… · the same entry in another collection · chain H against H, TM-score 1.00
- Q8IUQ4 · AlphaFold monomer V2.0 prediction for E3 ubiquitin-protein ligase SIAH1 (Q8IUQ4) · a predicted model of the same protein · chain A against A, TM-score 0.95
- O15169 · AlphaFold monomer V2.0 prediction for axin-1 (O15169) · a predicted model of the same protein · chain H against A, TM-score 0.43
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8IUQ4
- Every structure of UniProt O15169
- Elsewhere: RCSB PDB 5WZZ · PDBe 5WZZ · UniProt Q8IUQ4 · UniProt O15169
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