UniProt O15169
Axin-1 (O15169)
Axin-1 (UniProt O15169): 28 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 7 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O15169
- Protein
- Axin-1
- Experimental structures
- 28
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 7 · 2 records with a druggable one
Structures
29 records of O15169 in the MolNFT archive: 28 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1DK8 | Crystal structure of the rgs-homologous domain of axin | x-ray diffraction | A | — | — |
| 1DK8 | Crystal structure of the rgs-homologous domain of axin | x-ray diffraction | A | — | — |
| 1EMU | Structure of the axin rgs-homologous domain in complex with a samp repeat from apc | x-ray diffraction | A | — | — |
| 1EMU | Structure of the axin rgs-homologous domain in complex with a samp repeat from apc | x-ray diffraction | A | — | — |
| 1O9U | Glycogen synthase kinase 3 beta complexed with axin peptide | x-ray diffraction | B | — | — |
| 1O9U | Glycogen synthase kinase 3 beta complexed with axin peptide | x-ray diffraction | B | — | — |
| 3ZDI | Glycogen Synthase Kinase 3 Beta complexed with Axin Peptide and Inhibitor 7d | x-ray diffraction | B | — | — |
| 3ZDI | Glycogen synthase kinase 3 beta complexed with axin peptide and inhibitor 7D | x-ray diffraction | B | — | — |
| 4B7T | Glycogen Synthase Kinase 3 Beta complexed with Axin Peptide and Leucettine L4 | x-ray diffraction | B | — | — |
| 4B7T | Glycogen synthase kinase 3 beta complexed with axin peptide and leucettine L4 | x-ray diffraction | B | — | — |
| 4NM0 | Crystal structure of peptide inhibitor-free GSK-3/Axin complex | x-ray diffraction | B | — | — |
| 4NM0 | Crystal structure of peptide inhibitor-free gsk-3/AXIN complex | x-ray diffraction | B | — | — |
| 4NM3 | Crystal structure of GSK-3/Axin complex bound to phosphorylated N-terminal auto-inhibitory pS9… | x-ray diffraction | B | — | — |
| 4NM3 | Crystal structure of gsk-3/AXIN complex bound to phosphorylated N- terminal auto-inhibitory PS9… | x-ray diffraction | B | — | — |
| 4NM5 | Crystal structure of GSK-3/Axin complex bound to phosphorylated Wnt receptor LRP6 c-motif | x-ray diffraction | B | — | — |
| 4NM5 | Crystal structure of gsk-3/AXIN complex bound to phosphorylated wnt receptor LRP6 C-motif | x-ray diffraction | B | — | — |
| 4NM7 | Crystal structure of GSK-3/Axin complex bound to phosphorylated Wnt receptor LRP6 e-motif | x-ray diffraction | B | — | — |
| 4NM7 | Crystal structure of gsk-3/AXIN complex bound to phosphorylated wnt receptor LRP6 E-motif | x-ray diffraction | B | — | — |
| 4NU1 | Crystal structure of a transition state mimic of the GSK-3/Axin complex bound to phosphorylated… | x-ray diffraction | B | — | — |
| 4NU1 | Crystal structure of a transition state mimic of the gsk-3/AXIN complex bound to phosphorylated… | x-ray diffraction | B | — | — |
| 5WZZ | The SIAH E3 ubiquitin ligases promote Wnt/ beta-catenin signaling through mediating Wnt-induced… | x-ray diffraction | E, F, G, H | — | 1 (best 0.71) |
| 5WZZ | The siah E3 ubiquitin ligases promote wnt/ beta-catenin signaling through mediating wnt-induced… | x-ray diffraction | E, F, G, H | — | — |
| 6JCK | Complex structure of Axin-DIX and Dvl2-DIX | x-ray diffraction | A | — | 1 (best 0.35) |
| 6JCK | Complex structure of axin-dix and DVL2-dix | x-ray diffraction | A | — | — |
| 7Y1P | CRYSTAL STRUCTURE OF THE RGS-HOMOLOGOUS DOMAIN OF AXIN IN COMPLEX WITH LZ-22Na | x-ray diffraction | A, B, C, D | I5L | 5 (best 0.53) |
| 8RU3 | Crystal structure of beta-catenin in complex with alpha-helical peptide inhibitor | x-ray diffraction | P | CL | — |
| 8RU4 | Crystal structure of Human Catenin Beta-1 in complex with stitched peptide inhibitor | x-ray diffraction | C | — | — |
| 8VMG | Crystal structure of GSK-3 26-383 bound to Axin 383-435 | x-ray diffraction | C, D | SO4, CL | — |
| O15169 | AlphaFold monomer V2.0 prediction for axin-1 (O15169) | predicted | A | — | — |
Ligands
Experiment against prediction
- 1EMU chain A against the predicted model O15169: TM-score 0.99, RMSD 0.47 Å
- 1EMU chain A against the predicted model O15169: TM-score 0.99, RMSD 0.47 Å
- 7Y1P chain C against the predicted model O15169: TM-score 0.99, RMSD 0.54 Å
- 7Y1P chain D against the predicted model O15169: TM-score 0.98, RMSD 0.58 Å
- 7Y1P chain A against the predicted model O15169: TM-score 0.98, RMSD 0.61 Å
- 7Y1P chain B against the predicted model O15169: TM-score 0.98, RMSD 0.66 Å
- 1DK8 chain A against the predicted model O15169: TM-score 0.95, RMSD 1.20 Å
- 1DK8 chain A against the predicted model O15169: TM-score 0.95, RMSD 1.20 Å
- 6JCK chain A against the predicted model O15169: TM-score 0.88, RMSD 1.43 Å
- 6JCK chain A against the predicted model O15169: TM-score 0.88, RMSD 1.43 Å
Elsewhere
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