MolNFT v1 · #29739 · protein

Structure of yeast oxysterol binding protein OSH4 in complex with ergosterol

1ZHZ · KES1 protein: “Structure of yeast oxysterol binding protein OSH4 in complex with ergosterol”. X-ray diffraction, 2 ligands (ERG, PB), 9 pockets (best druggability 0.85). MolNFT v1 #29739 on GenesisL1: 3D structure, binding sites and…

PDB: 1ZHZ
Type: protein
Length: 436 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: KES1 protein
UniProt: P35844
Ligands: ERG, PB
Pockets: 9 · best druggability 0.85

Structure

x-ray diffraction · 1 distinct chain · 32% helix, 28% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	KES1 protein	protein	436	32% helix, 28% strand	P35844

Ligands and binding sites

ERG · Ergosterol · ligand · chains A
PB · Lead (II) ion · metal · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

9 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	489	0.85	0.91	54	ERG
2	175	0.47	0.76	35	empty
3	164	0.46	0.76	25	empty
4	102	0.46	0.79	17	empty
5	87	0.43	0.79	23	empty

Compared structures

1ZHZ · Structure of yeast oxysterol binding protein Osh4 in complex with ergosterol · the same entry in another collection · chain A against A, TM-score 1.00
P35844 · AlphaFold monomer V2.0 prediction for oxysterol-binding protein homolog 4 (P35844) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P35844
Elsewhere: RCSB PDB 1ZHZ · PDBe 1ZHZ · UniProt P35844

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