Research workbench
Structure of yeast oxysterol binding protein OSH4 in complex with ergosterol
Analyse Structure of yeast oxysterol binding protein OSH4 in complex with ergosterol in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1ZHZ
- Type
- protein
- Length
- 436 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- KES1 protein
- UniProt
- P35844
- Ligands
- ERG, PB
- Pockets
- 9 · best druggability 0.85
Structure
x-ray diffraction · 1 distinct chain · 32% helix, 28% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | KES1 protein | protein | 436 | 32% helix, 28% strand | P35844 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
9 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 489 | 0.85 | 0.91 | 54 | ERG |
| 2 | 175 | 0.47 | 0.76 | 35 | empty |
| 3 | 164 | 0.46 | 0.76 | 25 | empty |
| 4 | 102 | 0.46 | 0.79 | 17 | empty |
| 5 | 87 | 0.43 | 0.79 | 23 | empty |
Compared structures
- 1ZHZ · Structure of yeast oxysterol binding protein Osh4 in complex with ergosterol · the same entry in another collection · chain A against A, TM-score 1.00
- P35844 · AlphaFold monomer V2.0 prediction for oxysterol-binding protein homolog 4 (P35844) · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P35844
- Elsewhere: RCSB PDB 1ZHZ · PDBe 1ZHZ · UniProt P35844
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