MolNFT v1 · #29155 · protein
Gppnhp-bound RAB21 GTPase at 2.05 a resolution
1YZT · RAS-related protein rab-21: “Gppnhp-bound RAB21 GTPase at 2.05 a resolution”. X-ray diffraction, 2 ligands (GNP, MG), 2 pockets (best druggability 0.57). MolNFT v1 #29155 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1YZT
- Type
- protein
- Length
- 309 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- RAS-related protein rab-21
- UniProt
- Q9UL25
- Ligands
- GNP, MG
- Pockets
- 2 · best druggability 0.57
Structure
x-ray diffraction · 2 distinct chains · 39% helix, 30% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | RAS-related protein rab-21 | protein | 155 | 39% helix, 30% strand | Q9UL25 |
| B | RAS-related protein rab-21 | protein | 154 | 38% helix, 31% strand | Q9UL25 |
Ligands and binding sites
- GNP · Phosphoaminophosphonic acid-guanylate ester · ligand · 2 copies · chains A, B
- MG · Magnesium ion · metal · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 144 | 0.57 | 0.83 | 28 | MG, GNP |
| 2 | 158 | 0.56 | 0.81 | 27 | MG, GNP |
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9UL25
- Elsewhere: RCSB PDB 1YZT · PDBe 1YZT · UniProt Q9UL25
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