MolNFT v1 · #27431 · protein

Structure of human annexin A2 in the presence of calcium ions

1XJL: “Structure of human annexin A2 in the presence of calcium ions”. X-ray diffraction, 1 ligand (CA), 6 pockets (best druggability 0.75). MolNFT v1 #27431 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1XJL
Type: protein
Length: 638 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Annexin A2
UniProt: P07355
Ligands: CA
Pockets: 6 · best druggability 0.75

Structure

x-ray diffraction · 1 distinct chain · 71% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Annexin A2	protein	319	71% helix, 0% strand	P07355

Ligands and binding sites

CA · Calcium ion · metal · 14 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

6 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1021	0.75	0.78	99	empty
2	149	0.55	0.82	24	empty
3	105	0.52	0.83	22	empty
4	136	0.51	0.80	24	empty
5	179	0.51	0.78	33	empty

Interfaces

1 interface between chains.

A–B · 394 Å² buried · 8 hydrogen bonds · protein-protein

Compared structures

1XJL · Structure of human annexin A2 in the presence of calcium ions · the same entry in another collection · chain A against A, TM-score 1.00
P07355 · AlphaFold monomer V2.0 prediction for annexin A2 (P07355) · a predicted model of the same protein · chain B against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P07355
Elsewhere: RCSB PDB 1XJL · PDBe 1XJL · UniProt P07355

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