MolNFT v1 · #26808 · protein

Crystal structure of tetrameric homoisocitrate dehydrogenase from an extreme thermophile, thermus thermophilus

1X0L: “Crystal structure of tetrameric homoisocitrate dehydrogenase from an extreme thermophile, thermus thermophilus”. X-ray diffraction, 4 pockets (best druggability 0.83). MolNFT v1 #26808 on GenesisL1: 3D structure, binding sites and…

PDB: 1X0L
Type: protein
Length: 659 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Homoisocitrate dehydrogenase
EC: 1.1.1.87
UniProt: Q8RQU4
Pockets: 4 · best druggability 0.83

Structure

x-ray diffraction · 2 distinct chains · 44% helix, 22% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Homoisocitrate dehydrogenase (EC 1.1.1.87)	protein	333	44% helix, 22% strand	Q8RQU4
B	Homoisocitrate dehydrogenase (EC 1.1.1.87)	protein	326	45% helix, 22% strand	Q8RQU4

Pockets

4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1133	0.83	0.84	110	empty
2	504	0.71	0.80	57	empty
3	383	0.70	0.82	45	empty
4	78	0.34	0.75	16	empty

Interfaces

1 interface between chains.

A–B · 1693 Å² buried · 28 hydrogen bonds · protein-protein

Compared structures

1X0L · Crystal structure of tetrameric homoisocitrate dehydrogenase from an extreme thermophile… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8RQU4
Elsewhere: RCSB PDB 1X0L · PDBe 1X0L · UniProt Q8RQU4

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