Research workbench
Crystal structure of tetrameric homoisocitrate dehydrogenase from an extreme thermophile, thermus thermophilus
Analyse Crystal structure of tetrameric homoisocitrate dehydrogenase from an extreme… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1X0L
- Type
- protein
- Length
- 659 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Homoisocitrate dehydrogenase
- EC
- 1.1.1.87
- UniProt
- Q8RQU4
- Pockets
- 4 · best druggability 0.83
Structure
x-ray diffraction · 2 distinct chains · 44% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Homoisocitrate dehydrogenase (EC 1.1.1.87) | protein | 333 | 44% helix, 22% strand | Q8RQU4 |
| B | Homoisocitrate dehydrogenase (EC 1.1.1.87) | protein | 326 | 45% helix, 22% strand | Q8RQU4 |
Pockets
4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1133 | 0.83 | 0.84 | 110 | empty |
| 2 | 504 | 0.71 | 0.80 | 57 | empty |
| 3 | 383 | 0.70 | 0.82 | 45 | empty |
| 4 | 78 | 0.34 | 0.75 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 1693 Ų buried · 28 hydrogen bonds · protein-protein
Compared structures
- 1X0L · Crystal structure of tetrameric homoisocitrate dehydrogenase from an extreme thermophile… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8RQU4
- Elsewhere: RCSB PDB 1X0L · PDBe 1X0L · UniProt Q8RQU4
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