MolNFT v1 · #25863 · protein
FACTOR7 - 413 complex
1W7X · Blood coagulation factor viia: “FACTOR7 - 413 complex”. X-ray diffraction, 3 ligands (413, CA, SO4), 2 pockets (best druggability 0.40). MolNFT v1 #25863 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1W7X
- Type
- protein
- Length
- 302 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Blood coagulation factor viia
- EC
- 3.4.21.21
- UniProt
- P08709
- Ligands
- 413, CA, SO4
- Pockets
- 2 · best druggability 0.40
Structure
x-ray diffraction · 2 distinct chains · 16% helix, 35% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| H | Blood coagulation factor viia (EC 3.4.21.21) | protein | 250 | 15% helix, 37% strand | P08709 |
| L | Blood coagulation factor viia (EC 3.4.21.21) | protein | 52 | 17% helix, 27% strand | P08709 |
Ligands and binding sites
- 413 · (S)-[(R)-2-(4-benzyloxy-3-methoxy-phenyl)-2-(4-carbamimidoyl-phenylamino)-acetylamino]-phenyl-acetic acid · ligand · chains H
- CA · Calcium ion · metal · chains H
- SO4 · Sulfate ion · ion · 4 copies · chains H, L
- GOL · Glycerol · additive · 2 copies · chains H
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 126 | 0.40 | 0.74 | 23 | empty |
| 2 | 106 | 0.39 | 0.76 | 23 | 413 |
Interfaces
1 interface between chains.
- H–L · 1016 Ų buried · 12 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 8 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P08709
- Elsewhere: RCSB PDB 1W7X · PDBe 1W7X · UniProt P08709
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