MolNFT v1 · #25807 · protein
Crystal structure of mouse ribonucleotide reductase subunit R2 under reducing conditions. a fully occupied dinuclear iron cluster and bound acetate.
1W69 · Ribonucleoside-diphosphate reductase M2 chain: “Crystal structure of mouse ribonucleotide reductase subunit R2 under reducing conditions. a fully occupied…”. X-ray diffraction, 1 ligand (FE2), 1 pocket (best druggability 0.52).…
- PDB
- 1W69
- Type
- protein
- Length
- 281 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ribonucleoside-diphosphate reductase M2 chain
- EC
- 1.17.4.1
- UniProt
- P11157
- Ligands
- FE2
- Pockets
- 1 · best druggability 0.52
Structure
x-ray diffraction · 1 distinct chain · 74% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Ribonucleoside-diphosphate reductase M2 chain (EC 1.17.4.1) | protein | 281 | 74% helix, 0% strand | P11157 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 129 | 0.52 | 0.81 | 19 | empty |
Compared structures
- 1W69 · Crystal Structure of Mouse Ribonucleotide Reductase Subunit R2 under Reducing Conditions.… · the same entry in another collection · chain A against A, TM-score 1.00
- P11157 · AlphaFold monomer V2.0 prediction for ribonucleoside-diphosphate reductase subunit M2… · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P11157
- Elsewhere: RCSB PDB 1W69 · PDBe 1W69 · UniProt P11157
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