MolNFT v1 · #346225 · protein
AlphaFold monomer V2.0 prediction for ribonucleoside-diphosphate reductase subunit M2 (P11157)
P11157: “AlphaFold monomer V2.0 prediction for ribonucleoside-diphosphate reductase subunit M2 (P11157)”. 4 pockets (best druggability 0.71). MolNFT v1 #346225 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- P11157
- Type
- protein
- Length
- 390 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x3298b100681D3A2372Bba3b2f282750dD71629B9
- Molecule
- Ribonucleoside-diphosphate reductase subunit M2
- UniProt
- P11157
- Pockets
- 4 · best druggability 0.71
Structure
1 distinct chain · 61% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Ribonucleoside-diphosphate reductase subunit M2 | protein | 390 | 61% helix, 0% strand | P11157 |
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 589 | 0.71 | 0.79 | 49 | empty |
| 2 | 305 | 0.61 | 0.79 | 35 | empty |
| 3 | 141 | 0.42 | 0.75 | 22 | empty |
| 4 | 73 | 0.30 | 0.74 | 19 | empty |
Compared structures
- 1XSM · Protein R2 of ribonucleotide reductase from mouse · an experimental structure of the same protein · chain A against A, TM-score 0.73
- 1XSM · Protein R2 of ribonucleotide reductase from mouse · an experimental structure of the same protein · chain A against A, TM-score 0.73
- 1H0O · Cobalt substitution of mouse R2 ribonucleotide reductase to model the reactive diferrous… · an experimental structure of the same protein · chain A against A, TM-score 0.73
- 1H0O · Cobalt substitution of mouse R2 ribonucleotide reductase to model the reactive diferrous… · an experimental structure of the same protein · chain A against A, TM-score 0.73
- 1H0N · Cobalt substitution of mouse R2 ribonucleotide reductase to model the reactive diferrous… · an experimental structure of the same protein · chain A against A, TM-score 0.73
- 1H0N · Cobalt substitution of mouse R2 ribonucleotide reductase to model the reactive diferrous… · an experimental structure of the same protein · chain A against A, TM-score 0.73
- 1W69 · Crystal Structure of Mouse Ribonucleotide Reductase Subunit R2 under Reducing Conditions.… · an experimental structure of the same protein · chain A against A, TM-score 0.72
- 1W69 · Crystal structure of mouse ribonucleotide reductase subunit R2 under reducing conditions.… · an experimental structure of the same protein · chain A against A, TM-score 0.72
- 1W68 · Crystal Structure of Mouse Ribonucleotide Reductase Subunit R2 under Oxidizing… · an experimental structure of the same protein · chain A against A, TM-score 0.72
- 1W68 · Crystal structure of mouse ribonucleotide reductase subunit R2 under oxidizing… · an experimental structure of the same protein · chain A against A, TM-score 0.72
- 1AFT · Small subunit C-terminal inhibitory peptide of mouse ribonucleotide reductase as bound to… · an experimental structure of the same protein · chain A against A, TM-score 0.02
- 1AFT · Small subunit C-terminal inhibitory peptide of mouse ribonucleotide reductase as bound to… · an experimental structure of the same protein · chain A against A, TM-score 0.02
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P11157
- Elsewhere: UniProt P11157 · AlphaFold DB P11157
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