Potent factor xa inhibitor in complex with bovine trypsin variant X(99/175/190)BT

Structure

x-ray diffraction · 1 distinct chain · 10% helix, 36% strand (DSSP).

Ligands and binding sites

• BBA · 2,7-bis-(4-amidinobenzylidene)-cycloheptan-1-one · ligand · chains T
• CA · Calcium ion · metal · chains T

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Modifications

Observed in the structure: 6 disulfide (disulfide).

Compared structures

• 1V2N · Potent factor XA inhibitor in complex with bovine trypsin variant X(99/175/190)bT · the same entry in another collection · chain T against T, TM-score 1.00
• 1TNH · Prediction of novel serine protease inhibitors · a predicted model of the same protein · chain T against A, TM-score 0.99
• 1TNL · Prediction of novel serine protease inhibitors · a predicted model of the same protein · chain T against A, TM-score 0.99
• 1TNI · Prediction of novel serine protease inhibitors · a predicted model of the same protein · chain T against A, TM-score 0.99
• 1TNJ · Prediction of novel serine protease inhibitors · a predicted model of the same protein · chain T against A, TM-score 0.99
• 1TNG · Prediction of novel serine protease inhibitors · a predicted model of the same protein · chain T against A, TM-score 0.99
• 1TNK · Prediction of novel serine protease inhibitors · a predicted model of the same protein · chain T against A, TM-score 0.99

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P00760
• Elsewhere: RCSB PDB 1V2N · PDBe 1V2N · UniProt P00760